5-methyl N-(2-hydroxybenzyl)sarcosine | 128837-43-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-methyl N-(2-hydroxybenzyl)sarcosine
• 英文别名: 2-[(2-Hydroxy-5-methylphenyl)methyl-methylamino]acetic acid
• CAS: 128837-43-4
• 化学式: C₁₁H₁₅NO₃
• 分子量: 209.245
• InChiKey: KWJGPIFLKBUHKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  60.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 对甲酚 、 肌氨酸 生成 5-methyl N-(2-hydroxybenzyl)sarcosine
  参考文献：
  名称：

  Phenolic Analogs of Amino Carboxylic-Acid Ligands for Tc-99m. 3. N-(2-Hydroxybenzyl) Sarcosines (Hbs)

  摘要：

  DOI：

  10.1071/ch9900783

文献信息

• Chelate compounds and their synthetic methods
  申请人：DISEASE ADSORPTION SYSTEM TECHNOLOGIES CO., LTD.

  公开号：US10308725B2

  公开（公告）日：2019-06-04

  A chelate compound wherein a chelate-forming moiety is attached to a base compound having an amino group and at least a part of the amino group is in the form of a halide salt. A specific example of the halide salt is hydrochloride. As the base compound, a chitosan having a glucosamine skeleton is preferred. Also, chitosan beads are usable. The chelate compound is produced by reacting the base compound having an amino group with an aldehyde group of an aromatic cyclic compound, aromatic cyclic compound having at least a functional group capable of forming a chelate and the aldehyde group, to form a Schiff base, reducing the Schiff base with a reducing agent and then treating with a hydrohalogenic acid (hydrochloric acid).

  一种螯合物，其中的螯合形成分子连接到具有氨基的基化合物上，氨基的至少一部分以卤化物盐的形式存在。卤化盐的一个具体例子是盐酸盐。作为基化合物，优选具有氨基葡萄糖骨架的壳聚糖。此外，壳聚糖珠也可以使用。螯合物的制备方法是将具有氨基的基化合物与芳香族环状化合物的醛基反应，芳香族环状化合物至少具有一个能形成螯合物的官能团和醛基，形成希夫碱，用还原剂还原希夫碱，然后用氢卤酸（盐酸）处理。
• CHELATE COMPOUNDS AND THEIR SYNTHETIC METHODS
  申请人：DISEASE ADSORPTION SYSTEM TECHNOLOGIES CO., LTD.

  公开号：US20170210828A1

  公开（公告）日：2017-07-27

  A chelate compound wherein a chelate-forming moiety is attached to a base compound having an amino group and at least a part of the amino group is in the form of a halide salt. A specific example of the halide salt is hydrochloride. As the base compound, a chitosan having a glucosamine skeleton is preferred. Also, chitosan beads are usable. The chelate compound is produced by reacting the base compound having an amino group with an aldehyde group of an aromatic cyclic compound, aromatic cyclic compound having at least a functional group capable of forming a chelate and the aldehyde group, to form a Schiff base, reducing the Schiff base with a reducing agent and then treating with a hydrohalogenic acid (hydrochloric acid).
• PHARMACEUTICAL COMPOSITION COMPRISING IRON CHELATOR EXHIBITING ANTITUMOR ACTIVITY, ANTIBACTERIAL ACTIVITY AND/OR ANTIVIRUS ACTIVITY, AND HAVING REDUCED SIDE EFFECTS
  申请人：Disease Adsorption System Technologies Co., Ltd.

  公开号：US20200163938A1

  公开（公告）日：2020-05-28

  The present invention provides a pharmaceutical composition comprising an iron chelating agent exhibiting antitumor activity, antimicrobial activity, and/or antivirus activity and having reduced side effects. Specifically, the present invention provides a pharmaceutical composition for use in treatment of cancer or infectious disease, comprising an iron chelating agent that selectively binds to biologically unstable iron, rather than to transferrin-bound iron.
• US9796605B2
  申请人：——

  公开号：US9796605B2

  公开（公告）日：2017-10-24
• Phenolic Analogs of Amino Carboxylic-Acid Ligands for Tc-99m. 3. N-(2-Hydroxybenzyl) Sarcosines (Hbs)
  作者：JG Wilson

  DOI：10.1071/ch9900783

  日期：——