[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyanilino] methanesulfonate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyanilino] methanesulfonate
• 化学式: C₂₉H₃₄N₆O₇S
• 分子量: 610.7
• InChiKey: YTPKVQHVTWOBDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  43
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  148
• 氢给体数：
  1
• 氢受体数：
  12

文献信息

• SOLID DISPERSION WITH IMPROVED SOLUBILITY COMPRISING TETRAZOLE DERIVATIVE AS AN ACTIVE INGREDIENT
  申请人：Hanmi Pharm. Co., Ltd.

  公开号：EP2931720B1

  公开（公告）日：2019-04-24
• US9283218B2
  申请人：——

  公开号：US9283218B2

  公开（公告）日：2016-03-15
• [EN] SOLID DISPERSION WITH IMPROVED SOLUBILITY COMPRISING TETRAZOLE DERIVATIVE AS AN ACTIVE INGREDIENT<br/>[FR] DISPERSION SOLIDE AYANT UNE SOLUBILITÉ AMÉLIORÉE COMPRENANT UN DÉRIVÉ DE TÉTRAZOLE EN TANT QUE SUBSTANCE ACTIVE
  申请人：HANMI PHARM IND CO LTD

  公开号：WO2014092489A1

  公开（公告）日：2014-06-19

  The present invention relates to an amorphous solid dispersion comprising a tetrazole derivative of the formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient. The solid dispersion of the present invention comprises a water-soluble polymer or an acid so as to improve the solubility of its active ingredient, i.e., the tetrazole derivative of the formula (I), thereby improving its absorption rate, and thus can be effectively used to reduce multi-drug resistance (MDR) in cancer cells.