15-Tert-butyl-6-(2,2-dimethylpropyl)-3,3,4,4,9,9,10,10-octamethyl-13,14,15-triazatetracyclo[10.3.0.02,5.08,11]pentadeca-1(12),2(5),8(11),13-tetraene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 15-Tert-butyl-6-(2,2-dimethylpropyl)-3,3,4,4,9,9,10,10-octamethyl-13,14,15-triazatetracyclo[10.3.0.02,5.08,11]pentadeca-1(12),2(5),8(11),13-tetraene
• 英文别名: 15-tert-butyl-6-(2,2-dimethylpropyl)-3,3,4,4,9,9,10,10-octamethyl-13,14,15-triazatetracyclo[10.3.0.02,5.08,11]pentadeca-1(12),2(5),8(11),13-tetraene
• 化学式: C₂₉H₄₇N₃
• 分子量: 437.7
• InChiKey: PGFPWJSJEVOPSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Polymer hydrogels for in vivo applications and methods for using and preparing same
  申请人：Murthy Niren

  公开号：US10039831B2

  公开（公告）日：2018-08-07

  Compositions and methods are described for a polymer hydrogel created by a cycloaddition reaction between an azide and an alkyne that proceeds rapidly without catalyst to produce the polymer hydrogel in less than ninety seconds. The polymer hydrogel can be used in in vivo applications for the localized delivery of therapeutic agent in aqueous solutions. An example of therapeutic delivery of a protein in a mouse model is demonstrated.

  本文描述了一种聚合物水凝胶的组成和方法，该聚合物水凝胶是通过叠氮化物和炔烃之间的环化反应生成的，该反应在不使用催化剂的情况下快速进行，可在九十秒内生成聚合物水凝胶。这种聚合物水凝胶可用于体内局部输送水溶液中的治疗剂。现举例说明在小鼠模型中输送蛋白质的治疗效果。
• Polymer Hydrogels For In Vivo Applications And Methods For Using And Preparing Same
  申请人：Murthy Niren

  公开号：US20140171367A1

  公开（公告）日：2014-06-19

  Compositions and methods are described for a polymer hydrogel created by a cycloaddition reaction between an azide and an alkyne that proceeds rapidly without catalyst to produce the polymer hydrogel in less than ninety seconds. The polymer hydrogel can be used in in vivo applications for the localized delivery of therapeutic agent in aqueous solutions. An example of therapeutic delivery of a protein in a mouse model is demonstrated.