1-(2-chlorophenyl)-N,5-diethyl-N-propylpyrazole-4-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(2-chlorophenyl)-N,5-diethyl-N-propylpyrazole-4-carboxamide
• 化学式: C₁₇H₂₂ClN₃O
• 分子量: 319.8
• InChiKey: MWQGCQJZGVQTJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  38.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] MODULATION OF THYMOSIN BETA-4 IN SKIN<br/>[FR] MODULATION DE THYMOSINE BÊTA-4 DANS LA PEAU
  申请人：AVON PROD INC

  公开号：WO2014093053A1

  公开（公告）日：2014-06-19

  Methods for preventing, ameliorating, or reducing dermatological signs of inflammation are provided which employ active agents, other than a retinoid, that stimulate thymosin beta-4 expression in the skin and inhibit production of pro-imflammatory chemokines and /or cytokines. Also provided are methods for screening for substances which stimulate thymosin beta-4 expression levels and the methods of using active agents identified by the screening protocol in the treatment of skin.