(3R,4S,5S,6R)-2-[[2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-3,4-dihydro-2H-chromen-7-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: (3R,4S,5S,6R)-2-[[2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-3,4-dihydro-2H-chromen-7-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
• 化学式: C₂₁H₂₄O₁₁
• 分子量: 452.4
• InChiKey: VLFIBROLAXKPQK-ZGZXEJRTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  190
• 氢给体数：
  8
• 氢受体数：
  11

文献信息

• PHARMACEUTICAL COMPOSITION CONTAINING OLEANOLIC ACID ACETATE AS AN ACTIVE INGREDIENT FOR PREVENTING OR TREATING TLR- OR IL-6-MEDIATED DISEASES
  申请人：Korea Research Institute Of Bioscience And Biotechnology

  公开号：EP2823819A2

  公开（公告）日：2015-01-14

  The present invention relates to a pharmaceutical composition including oleanolic acid acetate or a pharmaceutically acceptable salt thereof as an active ingredient for preventing or treating TLR- and IL-6-mediated diseases, and a pharmaceutical composition including an adzuki bean extract containing the compound or the salt thereof, or a fraction thereof as an active ingredient for preventing or treating TLR- and IL-6-mediated diseases. The adzuki bean extract or the compound of the present invention is derived from a natural resource that has been used as a natural medicine for a long time, and it inhibits TLR-3 and TLR-7 activations induced by Poly(I:C) and Poly(I) which are synthetic analogues of dsRNA and ssRNA, blocks NF-κB-including signal transduction pathways, and inhibits transcriptional activation and phosphorylation of IL-6-activated inflammatory transcription factor STAT3 without causing side effects, thereby being widely used for the development of prophylactic or therapeutic agents for TLR-and IL-6-mediated diseases, for example, atopic dermatitis or arthritis.

  本发明涉及一种药物组合物，包括齐墩果酸乙酸酯或其药学上可接受的盐，作为预防或治疗TLR-和IL-6介导的疾病的活性成分；以及一种药物组合物，包括含有该化合物或其盐或其馏分的赤豆提取物，作为预防或治疗TLR-和IL-6介导的疾病的活性成分。本发明的赤豆提取物或化合物来源于一种长期以来被用作天然药物的自然资源，它能抑制由 Poly(I. C) 和 Poly(I. C) 诱导的 TLR-3 和 TLR-7 激活：C）和 Poly（I）（dsRNA 和 ssRNA 的合成类似物）诱导的 TLR-3 和 TLR-7 激活，阻断包括 NF-κB 在内的信号转导通路，抑制 IL-6 激活的炎性转录因子 STAT3 的转录激活和磷酸化，且不会产生副作用，因此可广泛用于开发 TLR 和 IL-6 介导的疾病（如特应性皮炎或关节炎）的预防或治疗药物。
• COMPOSITION COMPRISING OLEANOLIC ACID ACETATE AS ACTIVE INGREDIENT FOR PREVENTING, ALLEVIATING, OR TREATING RENAL TOXICITY INDUCED BY MEDICINE
  申请人：Korea Research Institute of Bioscience and Biotechnology

  公开号：EP3524239A1

  公开（公告）日：2019-08-14

  The present invention relates to a composition for preventing, improving or treating drug-induced nephrotoxicity, the composition comprising oleanolic acid acetate as an active ingredient. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating drug-induced nephrotoxicity comprising oleanolic acid acetate or a pharmaceutically acceptable salt thereof as an active ingredient, a health functional food for preventing or improving drug-induced nephrotoxicity comprising the active ingredients, and an anticancer adjuvant comprising the active ingredients. The oleanolic acid acetate of the present invention is derived from a natural product and has no side effects and no cytotoxicity and has excellent effects of preventing, improving and treating nephrotoxicity caused by a drug, particularly a platinum-based anticancer drug, so that it can be utilized as a pharmaceutical composition, a health functional food, and a cancer adjuvant thereof.

  本发明涉及一种用于预防、改善或治疗药物引起的肾毒性的组合物，该组合物包含齐墩果酸乙酸酯作为活性成分。更具体地说，本发明涉及一种用于预防或治疗药物引起的肾毒性的药物组合物，该组合物包含齐墩果酸醋酸盐或其药学上可接受的盐作为活性成分；一种用于预防或改善药物引起的肾毒性的保健功能食品，该保健功能食品包含该活性成分；以及一种抗癌辅助剂，该抗癌辅助剂包含该活性成分。本发明的齐墩果酸醋酸盐来源于天然产物，无副作用，无细胞毒性，对预防、改善和治疗由药物，特别是铂类抗癌药物引起的肾毒性有很好的效果，因此可用作药物组合物、保健功能食品及其抗癌辅助剂。
• OLEANOLIC ACID ACETATE AS AN ACTIVE INGREDIENT FOR PREVENTING OR TREATING TLR- OR IL-6-MEDIATED DISEASES
  申请人：Korea Research Institute of Bioscience and Biotechnology

  公开号：EP2823819B1

  公开（公告）日：2021-06-02