N-cyclopropyl glutaramic acid | 135449-68-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-cyclopropyl glutaramic acid
• 英文别名: 5-(Cyclopropylamino)-5-oxopentanoic acid
• CAS: 135449-68-2
• 化学式: C₈H₁₃NO₃
• mdl: MFCD03384603
• 分子量: 171.196
• InChiKey: JMPYPPGFJJUXLA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  戊二酸酐 、 cyclopropylamine hydrochloride 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以60%的产率得到N-cyclopropyl glutaramic acid
  参考文献：
  名称：

  Glutamine analogues as potential antimalarials

  摘要：

  Various N-substituted derivatives of glutamine, asparagine, glutaramic, succinamic and maleamic acids have been synthesized and tested in vitro against Plasmodium falciparum. From these compounds, only the glutamine derivatives (1-3) were found to have low activity. Kinetic evaluation of 1-3 revealed that these compounds also act as competitive inhibitors of gamma-glutamyl transpeptidase (EC 2.3.2.2).

  DOI：

  10.1016/0223-5234(91)90030-q

文献信息

• US7645771B2
  申请人：——

  公开号：US7645771B2

  公开（公告）日：2010-01-12
• Glutamine analogues as potential antimalarials
  作者：M Azoulay、M Vilmont、F Frappier

  DOI：10.1016/0223-5234(91)90030-q

  日期：1991.3

  Various N-substituted derivatives of glutamine, asparagine, glutaramic, succinamic and maleamic acids have been synthesized and tested in vitro against Plasmodium falciparum. From these compounds, only the glutamine derivatives (1-3) were found to have low activity. Kinetic evaluation of 1-3 revealed that these compounds also act as competitive inhibitors of gamma-glutamyl transpeptidase (EC 2.3.2.2).