5-cyclopentyl-3-propan-2-yl-1H-pyrazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-cyclopentyl-3-propan-2-yl-1H-pyrazole
• 化学式: C₁₁H₁₈N₂
• 分子量: 178.27
• InChiKey: QVYFRILZUOBJIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• FUSED PYRIMIDINE COMPOUNDS AND USE THEREOF
  申请人：MEDIVATION TECHNOLOGIES, INC.

  公开号：US20140179668A1

  公开（公告）日：2014-06-26

  Fused pyrimidine compounds as kinase inhibitors, such as multi-kinase inhibitors, are provided. Fused pyrimidine compounds as IGF-IR inhibitors are provided. The compounds may be used in a method of treating cancer. Pharmaceutical compositions containing a fused pyrimidine compound and a pharmaceutically acceptable carrier are also provided, as are kits containing a fused pyrimidine compound or salt thereof and instructions for use, e.g., in a method of treating cancer.

  提供了融合嘧啶化合物作为激酶抑制剂，如多激酶抑制剂。提供了融合嘧啶化合物作为IGF-IR抑制剂。这些化合物可用于治疗癌症的方法。还提供了含有融合嘧啶化合物和药用载体的药物组合物，以及含有融合嘧啶化合物或其盐和使用说明的试剂盒，例如用于治疗癌症的方法。
• [EN] PYRIMIDINE DERIVATIVES AS TROPOMYOSIN RECEPTOR KINASE A (TRKA) INHIBITORS<br/>[FR] DÉRIVÉS DE PYRIMIDINE UTILISÉS EN TANT QU'INHIBITEURS DU RÉCEPTEUR DE KINASE A LIÉ À LA TROPOMYOSINE (TRKA)
  申请人：BIOMED X GMBH

  公开号：WO2019101843A1

  公开（公告）日：2019-05-31

  The present invention relates to novel TrkA inhibitors ofofmrula (1) which are useful in the treatment or prevention of acute and chronic pain but also for other abnormal activities of TrkA beyond pain therapy, such as inflammation and cancer.

  本发明涉及一种新型TrkA抑制剂，其化学式为（1），该抑制剂可用于治疗或预防急性和慢性疼痛，但也可用于治疗TrkA在疼痛治疗之外的其他异常活动，如炎症和癌症。
• Pyrimidine Derivatives as Tropomyosin Receptor Kinase A (TRKA) Inhibitors
  申请人：BIOMED X GMBH

  公开号：US20200399250A1

  公开（公告）日：2020-12-24

  The present invention relates to novel TrkA inhibitors of formula (1) which are useful in the treatment or prevention of acute and chronic pain but also for other abnormal activities of TrkA beyond pain therapy, such as inflammation and cancer.
• US9422267B2
  申请人：——

  公开号：US9422267B2

  公开（公告）日：2016-08-23
• US9499519B2
  申请人：——

  公开号：US9499519B2

  公开（公告）日：2016-11-22