2-(4-cyano-2-fluoro-5-methoxyphenyl)-N-(3-hydroxypropyl)-N-[2-[2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethylamino]ethyl]acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异香豆素
• 英文名称: 2-(4-cyano-2-fluoro-5-methoxyphenyl)-N-(3-hydroxypropyl)-N-[2-[2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethylamino]ethyl]acetamide
• 化学式: C₂₆H₃₀FN₃O₅
• 分子量: 483.5
• InChiKey: ABPZGAKCQSUSMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  35
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• [EN] INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL<br/>[FR] INHIBITEURS DU CANAL POTASSIQUE MÉDULLAIRE EXTERNE RÉNAL
  申请人：MERCK SHARP & DOHME

  公开号：WO2014099633A2

  公开（公告）日：2014-06-26

  The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kirl.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.