1-Tert-butyl-4-(3-fluorophenyl)triazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-Tert-butyl-4-(3-fluorophenyl)triazole
• 英文别名: 1-tert-butyl-4-(3-fluorophenyl)triazole
• 化学式: C₁₂H₁₄FN₃
• 分子量: 219.26
• InChiKey: IKKHUAWGXPEZQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists
  申请人：GLYCOMIMETICS, INC.

  公开号：US11197877B2

  公开（公告）日：2021-12-14

  Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin to an E-selectin ligand are disclosed. For example, E-selectin antagonists are described and pharmaceutical compositions comprising at least one of the same.

  本文公开了通过抑制 E-选择素与 E-选择素配体的结合来治疗和/或预防至少一种疾病、失调和/或病症的化合物、组合物和方法。例如，描述了 E-选择素拮抗剂和包含至少一种 E-选择素拮抗剂的药物组合物。
• HETEROBIFUNCTIONAL PAN-SELECTIN INHIBITORS
  申请人：GLYCOMIMETICS, INC.

  公开号：US20140178303A1

  公开（公告）日：2014-06-26

  Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
• HIGHLY POTENT MULTIMERIC E-SELECTIN ANTAGONISTS
  申请人：GLYCOMIMETICS, INC.

  公开号：US20190233458A1

  公开（公告）日：2019-08-01

  Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin to an E-selectin ligand are disclosed. For example, highly potent multimeric E-selectin antagonist are dessorbed and pharmaceutical compositions comprising at least one of the same.
• GALACTOPYRANOSYL-CYCLOHEXYL DERIVATIVES AS E-SELECTIN ANTAGONISTS
  申请人：GLYCOMIMETICS, INC.

  公开号：US20200129536A1

  公开（公告）日：2020-04-30

  Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin to an E-selectin ligand are disclosed. For example, E-selectin antagonists are described and pharmaceutical compositions comprising at least one of the same.
• Heterobifunctional Pan-Selectin Antagonists Having a Triazole Linker
  申请人：GlycoMimetics, Inc.

  公开号：US20200171005A9

  公开（公告）日：2020-06-04

  Compounds, compositions, and methods for modulating in vitro and in vivo processes mediated by selectin binding. For example, heterobifunctional compounds that inhibit both E-selectins and P-selectins are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids). The compounds are of formula (Ia) wherein the substituents are as defined in the claims.