2-amino-4-phenyl-(S)-3-butenoic acid | 127643-99-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-amino-4-phenyl-(S)-3-butenoic acid
• 英文别名: (Z,2S)-2-amino-4-phenylbut-3-enoic acid
• CAS: 127643-99-6
• 化学式: C₁₀H₁₁NO₂
• 分子量: 177.203
• InChiKey: JDMFMPYPEPMAGS-NMTCXDENSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  t-butyl 2-benzyloxycarbonylamino-4-phenyl-(S)-3-butenoate 在 氢溴酸 作用下， 以 溶剂黄146 为溶剂， 反应 0.75h， 生成 2-amino-4-phenyl-(S)-3-butenoic acid 、 (3E,2S)-2-amino-4-phenyl-3-butenoic acid
  参考文献：
  名称：

  非蛋白氨基酸合成：由天冬氨酸合成β，γ-不饱和α-氨基酸

  摘要：

  描述了使用衍生自天冬氨酸的β-阴离子进行的一般立体定向的β，γ-不饱和α-氨基酸的合成。

  DOI：

  10.1016/s0040-4020(01)85141-3

文献信息

• Peptide with safer secondary structure, peptide library, and production methods for same
  申请人：The University of Tokyo

  公开号：US10435439B2

  公开（公告）日：2019-10-08

  An object of the invention is to provide a peptide having a stabilized secondary structure. The present invention provides a peptide having a secondary structure stabilized by a crosslinked structure and containing at least one combination of a special amino acid of the formula (I): (wherein, (A) represents a single bond or a linking group having, in the main chain thereof, from 1 to 10 atoms; (B) represents a group containing at least one π bond; (C) represents a hydrogen atom or an alkyl group which may be substituted with a substituent; and X represents a group substitutable by a substitution reaction with a sulfanyl group) and an amino acid having, in the side chain thereof, a sulfanyl group; and having the crosslinked structure formed through a thioether bond between the side chain of the special amino acid residue and the sulfanyl group.

  本发明的目的是提供一种具有稳定二级结构的多肽。 本发明提供了一种多肽，它具有通过交联结构稳定的二级结构，并含有至少一种式（I）的特殊氨基酸组合： (其中，(A)代表单键或在其主链中具有 1 至 10 个原子的连接基团； (B) 代表至少含有一个 π 键的基团； (C) 代表氢原子或可被取代基取代的烷基；以及 X 代表可通过取代反应被硫酰基取代的基团）和在其侧链中具有硫酰基的氨基酸；并具有通过特殊氨基酸残基侧链和硫酰基之间的硫醚键形成的交联结构。
• Peptide with Safer Secondary Structure, Peptide Library, and Production Methods for Same
  申请人：The University of Tokyo

  公开号：US20170247416A1

  公开（公告）日：2017-08-31

  An object of the invention is to provide a peptide having a stabilized secondary structure. The present invention provides a peptide having a secondary structure stabilized by a crosslinked structure and containing at least one combination of a special amino acid of the formula (I): (wherein, (A) represents a single bond or a linking group having, in the main chain thereof, from 1 to 10 atoms; (B) represents a group containing at least one it bond; (C) represents a hydrogen atom or an alkyl group which may be substituted with a substituent; and X represents a group substitutable by a substitution reaction with a sulfanyl group) and an amino acid having, in the side chain thereof, a sulfanyl group; and having the crosslinked structure formed through a thioether bond between the side chain of the special amino acid residue and the sulfanyl group.
• US9657289B2
  申请人：——

  公开号：US9657289B2

  公开（公告）日：2017-05-23
• Non-proteinogenic amino acid synthesis: Synthesis of β,γ-unsaturated α-amino acids from asparic acid
  作者：Jack E Baldwin、Mark G Moloney、Michael North

  DOI：10.1016/s0040-4020(01)85141-3

  日期：1989.1

  A general, stereospecific, synthesis of β,γ-unsaturated α-amino acids using the β-anion derived from aspartic acid is described.

  描述了使用衍生自天冬氨酸的β-阴离子进行的一般立体定向的β，γ-不饱和α-氨基酸的合成。