2-(3,4-dihydroxy-phenyl)-7-hydroxy-5-methyl-chromen-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-(3,4-dihydroxy-phenyl)-7-hydroxy-5-methyl-chromen-4-one
• 英文别名: 2-(3,4-Dihydroxy-phenyl)-7-hydroxy-5-methyl-chromen-4-on；2-(3,4-Dihydroxyphenyl)-7-hydroxy-5-methylchromen-4-one；2-(3,4-dihydroxyphenyl)-7-hydroxy-5-methylchromen-4-one
• 化学式: C₁₆H₁₂O₅
• 分子量: 284.268
• InChiKey: BUKJEIGDNKOBRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢碘酸 作用下， 生成 2-(3,4-dihydroxy-phenyl)-7-hydroxy-5-methyl-chromen-4-one
  参考文献：
  名称：

  Tambor, Chemische Berichte, 1908, vol. 41, p. 796

  摘要：

  DOI：

文献信息

• MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY
  申请人：THE GENERAL HOSPITAL CORPORATION

  公开号：US20140187510A1

  公开（公告）日：2014-07-03

  The present invention is directed toward a method of treating a subject for a condition mediated by aberrant Wnt/β-catenin signaling by selecting a subject with a condition mediated by aberrant Wnt/β-catenin signaling and administering to the selected subject a compound selected from the group consisting of those set forth in Table 1, Table 2, and a pharmaceutically acceptable salt thereof. A method of similarly modulating the Wnt/β-catenin pathway in a subject is also discussed.
• Compositions and Methods for Enhancing Bioenergetic Status in Female Germ Cells
  申请人：The General Hospital Corporation

  公开号：US20160024527A1

  公开（公告）日：2016-01-28

  Compositions and methods comprising bioenergetic agents for restoring the quality of aged oocytes, enhancing oogonial stem cells or improving derivatives thereof (e.g., cytoplasm or isolated mitochondria) for use in fertility-enhancing procedures, are described.
• SMALL MOLECULE CD38 INHIBITORS AND METHODS OF USING SAME
  申请人：President and Fellows of Harvard College

  公开号：US20180085383A1

  公开（公告）日：2018-03-29

  The invention provides methods and compositions for inhibiting CD38 activity, and methods of treating or preventing various disorders associated with CD38 activity.
• FLAVONOIDE-TYPE COMPOUNDS BEARING AN O-RHAMNOSYL RESIDUE
  申请人：Universitaet Hamburg

  公开号：US20190100549A1

  公开（公告）日：2019-04-04

  The present invention relates to compounds of formula (II) useful in the treatment of many diseases such as a skin disease, an allergy, an autoimmune disease, a cardiovascular disease, a lung disease, asthma, a bacterial, viral or parasitic disease, metabolic syndrome, cancer, Alzheimer's disease or diabetes and are furthermore useful in the preparation of cosmetics and for use in food and animal feed.