4-chloro-N-(1-(3,4-dichlorophenyl)-1H-1,2,3-triazol-4-yl)-N-(2-morpholinoethyl) benzenesulfonamide hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-chloro-N-(1-(3,4-dichlorophenyl)-1H-1,2,3-triazol-4-yl)-N-(2-morpholinoethyl) benzenesulfonamide hydrochloride
• 英文别名: 4-chloro-N-[1-(3,4-dichlorophenyl)triazol-4-yl]-N-(2-morpholin-4-ylethyl)benzenesulfonamide;hydrochloride
• 化学式: C₂₀H₂₀Cl₃N₅O₃S*(x)ClH
• 分子量: 553.3
• InChiKey: PBLBPVBXILBKDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.18
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  88.9
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• 1,2,3-triazole-4-amine derivatives for the treatment of sigma receptor related diseases and disorders
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP2752411A1

  公开（公告）日：2014-07-09

  The present invention relates to new 1,2,3-triazole-amine derivatives of general formula (I), having affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments for the treatment of sigma receptor related diseases and disorders.

  本发明涉及一种新的具有对西格玛受体（尤其是西格玛-1受体）亲和力的1,2,3-三唑胺衍生物，其一般式为（I），以及其制备方法、包含它们的组合物，以及它们作为治疗西格玛受体相关疾病和紊乱的药物的用途。
• 1,2,3-TRIAZOLE-4-AMINE DERIVATIVES FOR THE TREATMENT OF SIGMA RECEPTOR RELATED DISEASES AND DISORDERS
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：US20150353510A1

  公开（公告）日：2015-12-10

  The present invention relates to new 1,2,3-triazole-amine derivatives, having affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments for the treatment of sigma receptor related diseases and disorders.

  本发明涉及新的1,2,3-三唑胺衍生物，具有对σ受体，尤其是σ-1受体的亲和力，以及其制备过程、包含它们的组合物以及它们作为治疗σ受体相关疾病和疾病的药物的用途。
• US9611229B2
  申请人：——

  公开号：US9611229B2

  公开（公告）日：2017-04-04