4-(5-cyclopropyl-2,4-dihydroxyphenyl)-3-(1,2,3-trimethylindol-5-yl)-1H-imidazole-2-thione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(5-cyclopropyl-2,4-dihydroxyphenyl)-3-(1,2,3-trimethylindol-5-yl)-1H-imidazole-2-thione
• 化学式: C₂₃H₂₃N₃O₂S
• 分子量: 405.5
• InChiKey: UKXFEDZJGKMWFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  92.8
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• COMBINATION THERAPY OF HSP90 INHIBITORY COMPOUNDS WITH CHK INHIBITORS
  申请人：Proia David

  公开号：US20140194388A1

  公开（公告）日：2014-07-10

  A pharmaceutical composition comprising a CHK inhibitor, and an Hsp90 inhibitor according to the following formulae or tautomers, or pharmaceutically acceptable salts thereof, wherein the variables in the structural formulae are defined herein. Also provided are methods for treating a proliferative disorder in a subject in need thereof, using pharmaceutical compositions described herein.