4-{8-amino-3-[(6R,8aS)-3-oxooctahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-(2-ethoxyethoxy)-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide | 1620675-20-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-{8-amino-3-[(6R,8aS)-3-oxooctahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-(2-ethoxyethoxy)-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
• 英文别名: 4-[8-amino-3-[(6R,8aS)-3-oxo-2,5,6,7,8,8a-hexahydro-1H-indolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl]-3-(2-ethoxyethoxy)-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
• CAS: 1620675-20-8
• 化学式: C₃₁H₃₂F₃N₇O₄
• 分子量: 623.635
• InChiKey: HBDCZNNTRIHQRA-CTNGQTDRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  45
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  137
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• BTK INHIBITORS
  申请人：KIM RONALD M.

  公开号：US20140206681A1

  公开（公告）日：2014-07-24

  The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.

  本发明提供了根据式I提供的Bruton's酪氨酸激酶（Btk）抑制剂化合物，或其药学上可接受的盐，或包含这些化合物的药物组合物，并且用于治疗的使用。具体地，本发明涉及在治疗Btk介导的疾病中使用Btk抑制剂化合物。
• [EN] BTK INHIBITORS<br/>[FR] INHIBITEURS DE BTK
  申请人：MERCK SHARP & DOHME

  公开号：WO2014114185A1

  公开（公告）日：2014-07-31

  The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.

  本发明提供了根据式I或其药学上可接受的盐制备的Bruton's酪氨酸激酶（Btk）抑制剂化合物，或包含这些化合物的药物组合物，并且提供了这些化合物在治疗中的应用。具体而言，本发明涉及在治疗Btk介导的疾病中使用Btk抑制剂化合物。
• Process for producing flame-retardant porous materials based on polyurea
  申请人：BASF SE

  公开号：US10125232B2

  公开（公告）日：2018-11-13

  The present invention relates to a process for producing flame-retardant porous materials comprising the following steps: (a) reacting at least one polyfunctional isocyanate (a1) and at least one polyfunctional aromatic amine (a2) in an organic solvent optionally in the presence of water as component (a3) and optionally in the presence of at least one catalyst (a5); and then (b) removing the organic solvent to obtain the organic porous material, where step (a) is carried out in the presence of at least one organic flame retardant as component (a4), where this flame retardant is soluble in the solvent. The invention further relates to the porous materials thus obtainable, and also to the use of the porous materials for thermal insulation.

  本发明涉及一种生产阻燃多孔材料的工艺，包括以下步骤： (a) 使至少一种多官能团异氰酸酯（a1）和至少一种多官能团芳香胺（a2）在有机 溶剂中反应，可选择有水作为组分（a3）存在，也可选择有至少一种催化剂 （a5）存在；然后 (b) 去除有机溶剂，得到有机多孔材料、 其中，步骤(a)是在至少一种有机阻燃剂作为组分（a4）存在的情况下进行的，这种阻燃剂可溶于溶剂。 本发明还涉及由此获得的多孔材料，以及多孔材料在隔热方面的用途。
• Composition that is suitable for producing polyurethane foams and that contains at least one nucleating agent
  申请人：BASF SE

  公开号：US10988593B2

  公开（公告）日：2021-04-27

  Disclosed herein is a method for producing polyurethane or polyisocyanurate foams. The method involves reacting a composition (Z1) with at least one polyisocyanate, and occurs in the presence of at least one nucleating agent and a blowing agent, in which the nucleating agent and the blowing agent are mixed to obtain a composition (Z2) that is added to the composition (Z1) before it is reacted with the at least one polyisocyanate. The composition (Z1) contains (i) 100 parts by mass of a composition (ZP) including at least one polyol and at least one catalyst that catalyzes formation of a urethane, urea or isocyanuarate bond, and (ii) from 0.05 to 10 parts by mass of a surfactant TD having an HLB value below 6 and no silicon atom.

  本文公开了一种生产聚氨酯或聚异氰酸酯泡沫塑料的方法。该方法包括将一种组合物（Z1）与至少一种多异氰酸酯反应，并在至少一种成核剂和一种发泡剂存在的情况下进行，其中成核剂和发泡剂混合以获得一种组合物（Z2），该组合物在与至少一种多异氰酸酯反应之前加入到组合物（Z1）中。组合物 (Z1) 包含：(i) 100 重量份的组合物 (ZP)，包括至少一种多元醇和至少一种催化形成聚氨酯、脲或异氰酸酯键的催化剂；(ii) 0.05 至 10 重量份的表面活性剂 TD，其 HLB 值低于 6 且不含硅原子。
• PROCESS FOR PRODUCING FLAME-RETARDANT POROUS MATERIALS BASED ON POLYUREA
  申请人：BASF SE

  公开号：US20140206783A1

  公开（公告）日：2014-07-24

  The present invention relates to a process for producing flame-retardant porous materials comprising the following steps: (a) reacting at least one polyfunctional isocyanate (a1) and at least one polyfunctional aromatic amine (a2) in an organic solvent optionally in the presence of water as component (a3) and optionally in the presence of at least one catalyst (a5); and then (b) removing the organic solvent to obtain the organic porous material, where step (a) is carried out in the presence of at least one organic flame retardant as component (a4), where this flame retardant is soluble in the solvent. The invention further relates to the porous materials thus obtainable, and also to the use of the porous materials for thermal insulation.