1-(2-Hydroxyethyl)-3,3-dimethyl-1-[2-[[3-(3-methylphenyl)pyrazolo[1,5-a]pyrimidin-5-yl]amino]ethyl]urea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(2-Hydroxyethyl)-3,3-dimethyl-1-[2-[[3-(3-methylphenyl)pyrazolo[1,5-a]pyrimidin-5-yl]amino]ethyl]urea
• 英文别名: 1-(2-hydroxyethyl)-3,3-dimethyl-1-[2-[[3-(3-methylphenyl)pyrazolo[1,5-a]pyrimidin-5-yl]amino]ethyl]urea
• 化学式: C₂₀H₂₆N₆O₂
• 分子量: 382.5
• InChiKey: YUJVVKSVLJAXCL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  86
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• MACROCYCLIC LRRK2 KINASE INHIBITORS
  申请人：ONCODESIGN S.A.

  公开号：US20140206683A1

  公开（公告）日：2014-07-24

  The present invention relates to novel macrocylic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of LRRK2 (Leucine-Rich Repeat Kinase 2). Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine or diagnostic agent, in particular for the treatment and/or diagnosis of diseases characterized by LRRK2 kinase activity such as neurological disorders including Parkinson's disease and Alzheimer's disease.
• US9096609B2
  申请人：——

  公开号：US9096609B2

  公开（公告）日：2015-08-04