4-Ethenylindene-1,3-dione | 1228035-10-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 4-Ethenylindene-1,3-dione
• 英文别名: 4-ethenylindene-1,3-dione
• CAS: 1228035-10-6
• 化学式: C₁₁H₈O₂
• 分子量: 172.183
• InChiKey: FFMJUSLJYNXHFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  二硫化碳 、 4-Ethenylindene-1,3-dione 、 碘甲烷 在 potassium fluoride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以75%的产率得到2-(bis(methylthio)methylene)-4-vinyl-1H-indene-1,3(2H)-dione
  参考文献：
  名称：

  Methylene amine substituted arylindenopyrimidines as potent adenosine A2A/A1 antagonists

  摘要：

  A novel series of arylindenopyrimidines were identified as A(2A) and A(1) receptor antagonists. The series was optimized for in vitro activity by substituting the 8- and 9-positions with methylene amine substituents. The compounds show excellent activity in mouse models of Parkinson's disease when dosed orally. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.03.042
• 作为产物：
  描述：

  乙酸乙酯 、 dimethyl 3-ethenylbenzene-1,2-dicarboxylate 在 sodium hydride 、 盐酸 作用下， 以 乙醇 为溶剂， 生成 4-Ethenylindene-1,3-dione
  参考文献：
  名称：

  Methylene amine substituted arylindenopyrimidines as potent adenosine A2A/A1 antagonists

  摘要：

  A novel series of arylindenopyrimidines were identified as A(2A) and A(1) receptor antagonists. The series was optimized for in vitro activity by substituting the 8- and 9-positions with methylene amine substituents. The compounds show excellent activity in mouse models of Parkinson's disease when dosed orally. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.03.042

文献信息

• [EN] MACROMOLECULAR COMPOSITIONS COMPRISING INDENE-DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF<br/>[FR] COMPOSITIONS MACROMOLÉCULAIRES CONTENANT DES DÉRIVÉS D'INDÈNE , LEUR PRÉPARATION, ET LEUR UTILISATION
  申请人：STICHTING TECHNISCHE WETENSCHAPPEN

  公开号：WO2019110557A1

  公开（公告）日：2019-06-13

  The present invention relates to a method for preparing a macromolecular composition comprising indene-derivatives. The invention also relates to the macromolecular compositions per se, and to methods of using the macromolecular compositions. The macromolecular compositions are useful for undergoing subsequent reactions with small molecules.

  本发明涉及一种制备包含茚衍生物的高分子组合物的方法。该发明还涉及高分子组合物本身，以及使用这些高分子组合物的方法。这些高分子组合物可用于与小分子进行后续反应。
• Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof
  申请人：Stichting voor de Technische Wetenschappen

  公开号：US20200368721A1

  公开（公告）日：2020-11-26

  The present invention relates to a method for preparing a macromolecular composition comprising indene-derivatives. The invention also relates to the macromolecular compositions per se, and to methods of using the macromolecular compositions. The macromolecular compositions are useful for undergoing subsequent reactions with small molecules.
• Methylene amine substituted arylindenopyrimidines as potent adenosine A2A/A1 antagonists
  作者：Brian C. Shook、Stefanie Rassnick、Daniel Hall、Kenneth C. Rupert、Geoffrey R. Heintzelman、Kristen Hansen、Devraj Chakravarty、James L. Bullington、Robert H. Scannevin、Brian Magliaro、Lori Westover、Karen Carroll、Lisa Lampron、Ronald Russell、Shawn Branum、Kenneth Wells、Sandra Damon、Scott Youells、Xun Li、Mel Osbourne、Keith Demarest、Yuting Tang、Kenneth Rhodes、Paul F. Jackson

  DOI：10.1016/j.bmcl.2010.03.042

  日期：2010.5

  A novel series of arylindenopyrimidines were identified as A(2A) and A(1) receptor antagonists. The series was optimized for in vitro activity by substituting the 8- and 9-positions with methylene amine substituents. The compounds show excellent activity in mouse models of Parkinson's disease when dosed orally. (C) 2010 Elsevier Ltd. All rights reserved.