(5-Bromo-1,3-thiazol-2-yl) (2-methyltetrazol-5-yl) carbonate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (5-Bromo-1,3-thiazol-2-yl) (2-methyltetrazol-5-yl) carbonate
• 英文别名: (5-bromo-1,3-thiazol-2-yl) (2-methyltetrazol-5-yl) carbonate
• 化学式: C₆H₄BrN₅O₃S
• 分子量: 306.1
• InChiKey: IUSCGQGJTRZCDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  120
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• BIARYL HETEROCYCLE SUBSTITUTED OXAZOLIDINONE ANTIBACTERIAL AGENTS
  申请人：Xuanzhu Pharma Co., Ltd.

  公开号：US20140235584A1

  公开（公告）日：2014-08-21

  The present invention relates to a biaryl heterocycle substituted oxazolidinone antibacterials shown by general formula (I), a pharmaceutically acceptable salt thereof, an isomer or a prodrug thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , A and B are as defined in the description. The present invention further relates to a method for preparing the compound, a pharmaceutical composition and a pharmaceutical formulation comprising the compound, and a use of the compound in the manufacture of a medicament for the treatment and/or prevention of infectious diseases and a use for the treatment and/or prevention of infectious diseases.

  本发明涉及一种由一般式(I)所示的取代的双芳基杂环氧唑啉酮抗菌剂，其药学上可接受的盐，其异构体或其前药，其中R1、R2、R3、R4、R5、A和B如描述中所定义。本发明还涉及一种制备该化合物的方法，包括该化合物的药物组合物和药物配方，以及该化合物在制造用于治疗和/或预防传染病的药物和用于治疗和/或预防传染病的用途。
• BIARYL HETEROCYCLE SUBSTITUTED OXAZOLIDINON ANTIBACTERIAL DRUG
  申请人：Xuanzhu Pharma Co., Ltd.

  公开号：EP2762479A1

  公开（公告）日：2014-08-06

  The present invention relates to a biaryl heterocycle substituted oxazolidinone antibacterials shown by general formula (I), a pharmaceutically acceptable salt thereof, an isomer or a prodrug thereof, wherein R1, R2, R3, R4, R5, A and B are as defined in the description. The present invention further relates to a method for preparing the compound, a pharmaceutical composition and a pharmaceutical formulation comprising the compound, and a use of the compound in the manufacture of a medicament for the treatment and/or prevention of infectious diseases and a use for the treatment and/or prevention of infectious diseases.

  本发明涉及通式(I)所示的双芳基杂环取代的噁唑烷酮类抗菌剂、其药学上可接受的盐、异构体或原药，其中R1、R2、R3、R4、R5、A和B如描述中所定义。本发明进一步涉及制备该化合物的方法、包含该化合物的药物组合物和药物制剂，以及该化合物在制造治疗和/或预防传染性疾病的药物中的用途和治疗和/或预防传染性疾病的用途。
• US9359344B2
  申请人：——

  公开号：US9359344B2

  公开（公告）日：2016-06-07