N,3-dimethyl-5-phenyl-1,3-thiazol-3-ium-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N,3-dimethyl-5-phenyl-1,3-thiazol-3-ium-2-amine
• 化学式: C11H13N2S+
• 分子量: 205.3
• InChiKey: GWRGASKRZOSNND-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  44.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• INHIBITION OF CELL PROLIFERATION
  申请人：University of South Florida

  公开号：US20140221658A1

  公开（公告）日：2014-08-07

  The disclosed modulators of Rb:Raf-1 interactions are potent, selective disruptors of Rb:Raf-1 binding, with IC 50 values ranging from 80 nM to 500 nM. Further, these compounds are surprisingly effective in inhibiting a wide variety of cancer cells, including osteosarcoma, epithelial lung carcinoma, non-small cell lung carcinoma, three different pancreatic cancer cell lines, two different glioblastoma cell lines, metastatic breast cancer, melanoma, and prostate cancer. Moreover, the disclosed compounds effectively disrupt angiogenesis and significantly inhibited tumors in nude mice derived from human epithelial lung carcinoma tumors. Accordingly, the disclosed compounds, pharmaceutical compositions comprising the compounds, methods of inhibiting cell proliferation, methods of treating subjects with cancer, and methods of preparing the disclosed compounds are provided.
• US9656953B2
  申请人：——

  公开号：US9656953B2

  公开（公告）日：2017-05-23