5-甲氧基-6-甲基-1H-吲哚 | 3139-10-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 5-甲氧基-6-甲基-1H-吲哚
• 中文别名: 5-甲氧基-6-甲基吲哚；5-甲氧基-6-甲基-吲哚；6-甲基-5-甲氧基吲哚
• 英文名称: 5-Methoxy-6-methyl-1H-indole
• CAS: 3139-10-4
• 化学式: C₁₀H₁₁NO
• mdl: MFCD11007893
• 分子量: 161.2
• InChiKey: IIJZGWAVCFDDDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  25
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2933990090
• 危险性防范说明：
  P280
• 危险性描述：
  H302,H317

反应信息

• 作为反应物：
  描述：

  5-甲氧基-6-甲基-1H-吲哚 、 草酰氯 、 二甲胺 生成 2-(5-methoxy-6-methyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide
  参考文献：
  名称：

  GLENNON R. A.; SCHUBERT E.; JACYNO J. M.; ROSECRANS J. A., J. MED. CHEM., 1980, 23, NO 11, 1222-1226

  摘要：

  DOI：
• 作为产物：
  描述：

  (E)-2-(5-methoxy-4-methyl-2-nitrophenyl)-N,N-dimethylethenamine 、 溶剂黄146 生成 5-甲氧基-6-甲基-1H-吲哚
  参考文献：
  名称：

  GLENNON R. A.; SCHUBERT E.; JACYNO J. M.; ROSECRANS J. A., J. MED. CHEM., 1980, 23, NO 11, 1222-1226

  摘要：

  DOI：

文献信息

• QUINUCLIDINES FOR MODULATING ALPHA 7 ACTIVITY
  申请人：CoMentis, Inc.

  公开号：US20160009706A1

  公开（公告）日：2016-01-14

  Provided are substituted quinuclidine compounds, pharmaceutical compositions comprising such compounds, and methods of modulating α7 nicotinic acetylcholine receptors and treating neurological disorders using such compounds.

  提供了替代性的喹诺啡啶化合物，包括这些化合物的药物组合物，以及使用这些化合物调节α7烟碱乙酰胆碱受体和治疗神经系统疾病的方法。
• (AZA)INDOLE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES
  申请人：Shimizu Kazuo

  公开号：US20100056521A1

  公开（公告）日：2010-03-04

  The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level which has a uricosuric activity or the like. The present invention relates to (aza)indole derivatives represented by the following general formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, or salts thereof. In the formula (I), T represents nitro or cyano and the like; ring J represents aryl or heteroaryl and the like; Q represents carboxy or 5-tetazolyl and the like; Y represents H, OH, NH 2 , halogen, nitro, alkyl, alkoxy and the like; X 1 , X 2 and X 3 independently represent CR 2 or N; R 1 and R 2 independently represent halogen, cyano, haloalkyl, A-D-E-G, —N(-D-E-G) 2 and the like, in the formula, A represents a single bond, O, S and the like; D and G independently represent optionally substituted alkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene and the like; E represents a single bond, O, S, COO, SO 2 and the like.

  本发明提供了化合物，可用作预防或治疗与异常血清尿酸水平相关的疾病的药剂，具有尿酸排泄活性或类似活性。本发明涉及以下一般式（I）所表示的（aza）吲哚衍生物，其具有黄嘌呤氧化酶抑制活性，可用作预防或治疗与血清尿酸水平异常相关的疾病的药剂，其前体药物或盐。在公式（I）中，T代表硝基或氰基等；环J代表芳基或杂芳基等；Q代表羧基或5-四唑基等；Y代表H、OH、NH2、卤素、硝基、烷基、烷氧基等；X1、X2和X3独立地表示CR2或N；R1和R2独立地表示卤素、氰基、卤代烷基、A-D-E-G、-N（-D-E-G）2等，在式中，A表示单键，O，S等；D和G独立地表示可选的取代基的烷基，环烷基，杂环烷基，芳基，杂芳基等；E表示单键，O，S，COO，SO2等。
• ORGANIC COMPOUNDS CONTAINING SILICON OR GERMANIUM, TRANSITION METAL COMPLEXES, CATALYST FOR $g(a)-OLEFIN POLYMERIZATION, AND PROCESSES FOR PRODUCING $g(a)-OLEFIN POLYMERS
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：EP0985674A1

  公开（公告）日：2000-03-15

  An alkali metal- or alkali earth metal-containing organic compound (i) is reacted with a leaving group- and silicon- or germanium-containing compound (ii) in the presence of a nitrogen-containing aromatic heterocyclic compound. By such a method, it is possible to produce a silicon- or germanium-containing organic compound, for example, a cyclopentadienyl compound cross-linked by a silicon atom or a germanium atom, typically a cyclopentadienyl compound which is substituted with a substituted or unsubstituted silyl or germyl group, for a short time with a high yield.

  含碱金属或碱土金属的有机化合物(i)在含氮芳香杂环化合物存在下与离去基团和含硅或锗的化合物(ii)反应。通过这种方法，可以在短时间内以高产率生产出含硅或锗的有机化合物，例如，由硅原子或锗原子交联的环戊二烯基化合物，通常是由取代或未取代的硅基或锗基取代的环戊二烯基化合物。
• (Aza)indole derivative and use thereof for medical purposes
  申请人：Kissei Pharmaceutical Co., Ltd.

  公开号：EP2402314A1

  公开（公告）日：2012-01-04

  The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level which has a uricosuric activity or the like. The present invention relates to (aza)indole derivatives represented by the following general formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, or salts thereof. In the formula (I), T represents nitro or cyano and the like; ring J represents aryl or heteroaryl and the like; Q represents carboxy or 5-tetazolyl and the like; Y represents H, OH, NH2, halogen, nitro, alkyl, alkoxy and the like; X1, X2 and X3 independently represent CR2 or N; R1 and R2 independently represent halogen, cyano, haloalkyl, A-D-E-G; -N(-D-E-G)2 and the like, in the formula, A represents a single bond, O, S and the like; D and G independently represent optionally substituted alkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene and the like; E represents a single bond, O, S, COO, SO2 and the like.

  本发明提供了可用于预防或治疗与血清尿酸水平异常有关的疾病的化合物，这些化合物具有尿酸活性或类似活性。本发明涉及由以下通式(I)代表的具有黄嘌呤氧化酶抑制活性的(氮杂)吲哚衍生物，可用作预防或治疗与血清尿酸水平异常有关的疾病的制剂、其原药或其盐。在式 (I) 中，T 代表硝基或氰基等，环 J 代表芳基或杂芳基等，Q 代表羧基或 5-四唑基等，Y 代表 H、OH、NH2、卤素、硝基、烷基、烷氧基等，X1、X2 和 X3 独立地代表 CR2 或 N，R1 和 R2 独立地代表卤素、氰基、卤代烷基、A-D-E-G；-N(-D-E-G)2等，式中，A代表单键、O、S等；D和G独立地代表任选取代的亚烷基、环烷基、杂环烷基、芳基、杂芳基等；E代表单键、O、S、COO、SO2等。
• SUGASAWA T.; ADACHI M.; SASAKURA K.; KITAGAWA A., J. ORG. CHEM. 1979, 44, NO 4, 578-586
  作者：SUGASAWA T.、 ADACHI M.、 SASAKURA K.、 KITAGAWA A.

  DOI：——

  日期：——