L-Methyl-2-nicotinoylamino-valeriansaeure | 17274-87-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-Methyl-2-nicotinoylamino-valeriansaeure
• 英文别名: Nicotinoyl-L-leucin；N-(3-pyridinylcarbonyl)-L-leucine；DL-Leucine, N-(3-pyridinylcarbonyl)-；(2S)-4-methyl-2-(pyridine-3-carbonylamino)pentanoic acid
• CAS: 17274-87-2
• 化学式: C₁₂H₁₆N₂O₃
• mdl: MFCD00440525
• 分子量: 236.271
• InChiKey: IKBCYCIJCZFDFM-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  79.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  L-Methyl-2-nicotinoylamino-valeriansaeure 、 丙炔酸甲酯 在 乙酸酐 作用下， 反应 0.08h， 生成 2-(2-methylpropyl)-5-(3-pyridinyl)-1H-pyrrole-3-carboxylic acid methyl ester
  参考文献：
  名称：

  Microwave-assisted synthesis of pyridylpyrroles from N-acylated amino acids

  摘要：

  A small library of 3- and 4-pyridyl-substituted pyrroles was prepared from N-acylated amino acids. Nicotinoyl or isonicotinoyl chloride was used for the N-acylation of benzyl esters of amino acids. Debenzylation by palladium-catalyzed hydrogenation gave N-acylated amino acids. Dehydration of the acylated amino acids gave cyclic intermediates, manchnones or aziactones, which were treated in situ with alkynes in 1,3-dipolar cycloadditions. The starting materials were prepared in a parallel fashion, and microwave irradiation was used to facilitate the cycloaddition reactions. The regiochemistry of the cycloaddition was studied. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.09.094
• 作为产物：
  描述：

  N-(3-pyridinylcarbonyl)-L-leucine phenylmethyl ester 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 5.0h， 以98%的产率得到L-Methyl-2-nicotinoylamino-valeriansaeure
  参考文献：
  名称：

  Microwave-assisted synthesis of pyridylpyrroles from N-acylated amino acids

  摘要：

  A small library of 3- and 4-pyridyl-substituted pyrroles was prepared from N-acylated amino acids. Nicotinoyl or isonicotinoyl chloride was used for the N-acylation of benzyl esters of amino acids. Debenzylation by palladium-catalyzed hydrogenation gave N-acylated amino acids. Dehydration of the acylated amino acids gave cyclic intermediates, manchnones or aziactones, which were treated in situ with alkynes in 1,3-dipolar cycloadditions. The starting materials were prepared in a parallel fashion, and microwave irradiation was used to facilitate the cycloaddition reactions. The regiochemistry of the cycloaddition was studied. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.09.094

文献信息

• High concentration protein formulations with reduced viscosity
  申请人：Bhami's Research Laboratory, Pvt. Ltd.

  公开号：US10646569B2

  公开（公告）日：2020-05-12

  The present disclosure, among other things, provides low-viscosity, high concentration therapeutic protein agent formulations.

  本公开的内容包括提供低粘度、高浓度的治疗性蛋白制剂。
• Composition containing a penem or carbapenem antibiotic
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0226304B1

  公开（公告）日：1991-08-28
• HIGH CONCENTRATION PROTEIN FORMULATIONS WITH REDUCED VISCOSITY
  申请人：Bhami's Research Laboratory, Pvt. Ltd.

  公开号：EP3624846A1

  公开（公告）日：2020-03-25
• JPH035464A
  申请人：——

  公开号：JPH035464A

  公开（公告）日：1991-01-11
• US4757066A
  申请人：——

  公开号：US4757066A

  公开（公告）日：1988-07-12