O-Butyl-homoserin | 30382-36-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: O-Butyl-homoserin
• 英文别名: O-butyl-homoserine；2-Amino-4-butoxybutanoic acid
• CAS: 30382-36-6
• 化学式: C₈H₁₇NO₃
• 分子量: 175.228
• InChiKey: MNWJQZSYVCOGQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (2-Butoxyethyl)malonsaeure-diethylester 在 三(2-氯乙基)胺 、 硫酸 作用下， 生成 O-Butyl-homoserin
  参考文献：
  名称：

  Hayashi, Chemical and pharmaceutical bulletin, 1959, vol. 7, p. 187,190

  摘要：

  DOI：

文献信息

• Methods for the preparation of beta-amino acids
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20030113882A1

  公开（公告）日：2003-06-19

  Purified &bgr;-amino acids are of considerable interest in the preparation of pharmacologically active compounds and industrial precursors. Although enantiomerically pure &bgr;-amino acids can be produced by standard chemical synthesis, this traditional approach is time consuming, requires expensive starting materials, and results in a racemic mixture which must be purified further. However, DNA molecules encoding lysine 2,3-aminomutase can be used to prepare &bgr;-amino acids by methods that avoid the pitfalls of chemical synthesis. The present invention provides a method of producing enantiomerically pure &bgr;-amino acids from &agr;-amino acids comprising catalyzing the conversion of an &agr;-amino acid to a corresponding &bgr;-amino acid by utilizing a lysine 2,3-aminomutase as the catalyst.

  纯化的&bgr;-氨基酸在制备药理活性化合物和工业前体方面具有相当大的意义。虽然对映体纯的&bgr;-氨基酸可以通过标准化学合成法生产，但这种传统方法耗时长，需要昂贵的起始原料，而且会产生外消旋混合物，必须进一步纯化。然而，编码赖氨酸 2,3-氨基转化酶的 DNA 分子可以用来制备 &bgr;-氨基酸，其方法避免了化学合成的缺陷。本发明提供了一种从&agr;-氨基酸制备对映体纯&bgr;-氨基酸的方法，包括利用赖氨酸 2,3-氨基转化酶作为催化剂，催化&agr;-氨基酸转化为相应的&bgr;-氨基酸。
• SUPRAMOLECULAR POLYMERS AND COMPOSITIONS CONTAINING SAID POLYMERS
  申请人：Badel Thierry

  公开号：US20120289652A1

  公开（公告）日：2012-11-15

  Supramolecular polymers having repeat units connected by hydrogen bonds, where the repeat units are monomers, macromers, oligomers or polymers where at least one on the monomers contains at least one 2,5-diketopiperazine group are described. Composition prepared from these supramolecular polymers and articles produced from these compositions are also described.
• US7452701B2
  申请人：——

  公开号：US7452701B2

  公开（公告）日：2008-11-18
• US9012567B2
  申请人：——

  公开号：US9012567B2

  公开（公告）日：2015-04-21
• [EN] METHODS FOR THE PREPARATION OF beta-AMINO ACIDS<br/>[FR] PROCEDES DE PREPARATION DE DOLLAR G(B)-AMINOACIDES
  申请人：WISCONSIN ALUMNI RES FOUND

  公开号：WO2004021981A2

  公开（公告）日：2004-03-18

  Purified β-amino acids are of considerable interest in the preparation of pharmacologically active compounds and industrial precursors. Although enantiomerically pure β-amino acids can be produced by standard chemical synthesis, this traditional approach is time consuming, requires expensive starting materials, and results in a racemic mixture which must be purified further. However, DNA molecules encoding lysine 2,3-aminomutase can be used to prepare β-amino acids by methods that avoid the pitfalls of chemical synthesis. The present invention provides a method of producing enantiomerically pure β-amino acids from α-amino acids comprising catalyzing the conversion of an α-amino acid to a corresponding β-amino acid by utilizing a lysine 2,3-aminomutase as the catalyst.