5-Butan-2-yl-1-methylpyrazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-Butan-2-yl-1-methylpyrazole
• 英文别名: 5-butan-2-yl-1-methylpyrazole
• 化学式: C₈H₁₄N₂
• 分子量: 138.21
• InChiKey: HGBRXROPCCHZOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• THERAPEUTIC COMPOUNDS AND USES THEREOF
  申请人：Kala Pharmaceuticals, Inc.

  公开号：US20140235634A1

  公开（公告）日：2014-08-21

  Described herein are compounds of Formula (I) or Formula (VI), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of Formula (I) or Formula (VI) and pharmaceutical compositions thereof that are mucus penetrating. Methods of using the compounds or pharmaceutical compositions thereof for treating diseases are also provided.

  本文描述了公式（I）或公式（VI）的化合物，其药学上可接受的盐以及其药物组合物。还提供了包含公式（I）或公式（VI）化合物及其药物组合物的微粒（例如，纳米颗粒），这些微粒具有穿透黏液的特性。还提供了使用这些化合物或药物组合物治疗疾病的方法。
• [EN] HTT MODULATORS FOR TREATING HUNTINGTON'S DISEASE<br/>[FR] MODULATEURS HTT POUR LE TRAITEMENT DE LA MALADIE DE HUNTINGTON
  申请人：CHDI FOUNDATION INC

  公开号：WO2021231571A1

  公开（公告）日：2021-11-18

  Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.

  以下提供了一些作为HTT调节剂有用的化合物。这些化合物在亨廷顿病的治疗中很有用。
• Carboxamide derivatives and use thereof
  申请人：Purdue Pharma L.P.

  公开号：US10005768B2

  公开（公告）日：2018-06-26

  The present disclosure provides substituted pyridyl-, pyrimidinyl-, pyrazinyl-, pyridazinyl-, and triazinyl-based carboxamides of Formula I-A: and the pharmaceutically acceptable salts and solvates thereof, wherein Z, HET, R10, and E are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I-A to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.

  本公开提供了式 I-A 的取代吡啶基、嘧啶基、吡嗪基、哒嗪基和三嗪基羧酰胺： 及其药学上可接受的盐和溶液，其中 Z、HET、R10 和 E 的定义如说明书所述。本公开还涉及使用式 I-A 的化合物治疗对钠离子通道阻断有反应的疾病。本公开的化合物尤其适用于治疗疼痛。
• Pyridazinone compounds and uses thereof
  申请人：Edgewise Therapeutics, Inc.

  公开号：US11236065B2

  公开（公告）日：2022-02-01

  Substituted pyridazinone compounds, conjugates, and pharmaceutical compositions for use in the treatment of neuromuscular diseases, such as Duchenne Muscular Dystrophy (DMD), are disclosed herein. The disclosed compounds are useful, among other things, in the treating of DMD and modulating inflammatory inhibitors IL-1, IL-6 or TNF-α.

  本文公开了用于治疗神经肌肉疾病（如杜氏肌肉萎缩症（DMD））的取代哒嗪酮化合物、共轭物和药物组合物。所公开的化合物除其他外，可用于治疗 DMD 和调节炎症抑制剂 IL-1、IL-6 或 TNF-α。
• Carboxamide Derivatives and Use Thereof
  申请人：PURDUE PHARMA L.P.

  公开号：US20170096421A1

  公开（公告）日：2017-04-06

  The present disclosure provides substituted pyridyl-, pyrimidinyl-, pyrazinyl-, pyridazinyl-, and triazinyl-based carboxamides of Formula I-A: and the pharmaceutically acceptable salts and solvates thereof, wherein Z, HET, R 10 , and E are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I-A to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.