N-acetyl-D-aspartic acid anhydride | 41148-78-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-acetyl-D-aspartic acid anhydride
• 英文别名: N-Acetyl-D-asparaginsaeureanhydrid；n-Acetyl-d-aspartic acid anhydride；N-[(3R)-2,5-dioxooxolan-3-yl]acetamide
• CAS: 41148-78-1
• 化学式: C₆H₇NO₄
• 分子量: 157.126
• InChiKey: JMQITILRHSGUCB-SCSAIBSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  72.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-acetyl-D-aspartic acid anhydride 、 1-(4-氟苯基)乙胺 在 乙酸酐 作用下， 以 丙酮 为溶剂， 以85%的产率得到N-((3R)-1-(1-(4-fluorophenyl)ethyl)-2,5-dioxopyrrolidin-3-yl)acetamide
  参考文献：
  名称：

  Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: Highly potent against human enzyme within a cellular environment

  摘要：

  A series of 2,4,5-tri-substituted imidazoles has proven to be highly potent in inhibiting mammalian 15-lipoxygenase (15LO) with excellent selectivity over human isozymes 5- and P-12-LO. Non-symmetrical sulfamides (e.g., 21a-n) were found to be suitable replacements for the earlier arylsulfonamide-containing members of this series (e.g., 2, 14a-p). Several members of these series also demonstrated potent inhibition of human 15-LO in a cell-based assay. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.07.011

文献信息

• Imidazolyl inhibitors of 15-lipoxygenase
  申请人：Weinstein S. David

  公开号：US20050070588A1

  公开（公告）日：2005-03-31

  The present invention provides imidazolyl inhibitors of 15-LO, pharmaceutical compositions containing such inhibitors and methods for treating diseases related to the 15-LO cascade using such compounds and compositions.

  本发明提供了15-LO的咪唑基抑制剂，包含这些抑制剂的药物组合物以及使用这些化合物和组合物治疗与15-LO级联相关疾病的方法。
• L(S)- and D(R)-3-amino-1-phenylpyrrolidines. Stereoselective antagonists for histamine and acetylcholine receptors in vitro
  作者：Donald T. Witiak、Zuhair Muhi-Eldeen、Narain Mahishi、O. P. Sethi、Michael C. Gerald

  DOI：10.1021/jm00283a006

  日期：1971.1
• Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: Highly potent against human enzyme within a cellular environment
  作者：David S. Weinstein、Wen Liu、Khehyong Ngu、Charles Langevine、Donald W. Combs、Shaobin Zhuang、Cindy Chen、Cort S. Madsen、Timothy W. Harper、Jeffrey A. Robl

  DOI：10.1016/j.bmcl.2007.07.011

  日期：2007.9

  A series of 2,4,5-tri-substituted imidazoles has proven to be highly potent in inhibiting mammalian 15-lipoxygenase (15LO) with excellent selectivity over human isozymes 5- and P-12-LO. Non-symmetrical sulfamides (e.g., 21a-n) were found to be suitable replacements for the earlier arylsulfonamide-containing members of this series (e.g., 2, 14a-p). Several members of these series also demonstrated potent inhibition of human 15-LO in a cell-based assay. (c) 2007 Elsevier Ltd. All rights reserved.