Methyl 3-chloro-6-(fluoromethyl)-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: Methyl 3-chloro-6-(fluoromethyl)-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine-1-carboxylate
• 英文别名: methyl 3-chloro-6-(fluoromethyl)-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine-1-carboxylate
• 化学式: C₁₀H₁₂ClFN₂O₃
• 分子量: 262.66
• InChiKey: VXCFHXVDRRSYIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  53.4
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Tetrahydroimidazo(1,5-D)[1,4]Oxazepine Derivative
  申请人：Eisai R&D Management Co., Ltd.

  公开号：US20140243316A1

  公开（公告）日：2014-08-28

  A compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof works as an mGluR2 antagonist, and is applicable as a therapeutic agent for neurological disorders related to glutamate dysfunction and diseases involving the mGluR2, such as Alzheimer's disease: wherein R is a hydrogen atom, a C 1-6 alkyl group or the like, R 1 is a C 1-6 alkyl group, a C 1-6 alkoxy group or the like, R 2 is a halogen atom, a C 1-6 alkyl group, a C 1-6 alkoxy group or the like, R 3 is a hydrogen atom, a C 1-6 alkyl group or the like, and R 4 is a C 1-6 alkyl group or the like.

  以下公式（I）表示的化合物或其药用可接受盐作为mGluR2拮抗剂，可用作治疗与谷氨酸功能障碍相关的神经疾病和涉及mGluR2的疾病，如阿尔茨海默病：其中R是氢原子、C1-6烷基或类似物，R1是C1-6烷基、C1-6甲氧基或类似物，R2是卤素原子、C1-6烷基、C1-6甲氧基或类似物，R3是氢原子、C1-6烷基或类似物，R4是C1-6烷基或类似物。
• Tetrahydroimidazo[1,5-d][1,4]oxazepine compound
  申请人：Eisai R&D Management Co., Ltd.

  公开号：US20160052937A1

  公开（公告）日：2016-02-25

  A compound represented by formula (I): wherein R is a methyl group or the like, R 1 is a fluorine atom or the like, R 2 is a hydrogen atom or a fluorine atom, R 3 is a hydrogen atom, R 4 is an ethyl group or the like, or a pharmaceutically acceptable salt thereof.

  由以下式（I）表示的化合物：其中R是甲基基团或类似物，R1是氟原子或类似物，R2是氢原子或氟原子，R3是氢原子，R4是乙基基团或类似物，或其药学上可接受的盐。
• TETRAHYDROIMIDAZO[1,5-D][1,4]OXAZEPINE DERIVATIVE
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP2963043B1

  公开（公告）日：2018-05-30
• US9458176B2
  申请人：——

  公开号：US9458176B2

  公开（公告）日：2016-10-04