2,4-bis(2,4-bis(2,4-dimethylphenoxymethyl)phenoxymethyl)(3,3-diethyltriaz-1-en-1-yl)benzene | 1253261-44-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2,4-bis(2,4-bis(2,4-dimethylphenoxymethyl)phenoxymethyl)(3,3-diethyltriaz-1-en-1-yl)benzene
• 英文别名: N-[[2,4-bis[[2,4-bis[(2,4-dimethylphenoxy)methyl]phenoxy]methyl]phenyl]diazenyl]-N-ethylethanamine
• CAS: 1253261-44-7
• 化学式: C₆₀H₆₇N₃O₆
• 分子量: 926.208
• InChiKey: DSLBQSGCHKFHEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15
• 重原子数：
  69
• 可旋转键数：
  22
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  83.3
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  2,4-bis(2,4-bis(2,4-dimethylphenoxymethyl)phenoxymethyl)(3,3-diethyltriaz-1-en-1-yl)benzene 在 碘甲烷 作用下， 反应 72.0h， 以52%的产率得到2,4-bis(2,4-dimethylphenoxymethyl)iodobenzene
  参考文献：
  名称：

  Convergent Synthesis of Geometrically Disassembling Dendrimers using Cu(I)-Catalyzed C−O Bond Formation

  摘要：

  The convergent synthesis of geometrically degradable dendrimers based on the 2,4-bis(hydroxymethyl)phenol subunit is presented. The key step of the synthetic scheme involves the CuI/3,4,7,8-tetramethyl-1,10-phenanthroline-catalyzed coupling of aryl iodides and alcohols. The synthesis and disassembly of these compounds is discussed.

  DOI：

  10.1021/ol102081q
• 作为产物：
  描述：

  2,4-bishydroxymethyl(3,3-diethyltriaz-1-en-1-yl)benzene 、 2,4-bis(2,4-dimethylphenoxymethyl)iodobenzene 在 copper(l) iodide 、 3,4,7,8-四甲基-1,10-菲罗啉 、 caesium carbonate 作用下， 以 甲苯 为溶剂， 反应 72.0h， 以76%的产率得到2,4-bis(2,4-bis(2,4-dimethylphenoxymethyl)phenoxymethyl)(3,3-diethyltriaz-1-en-1-yl)benzene
  参考文献：
  名称：

  Convergent Synthesis of Geometrically Disassembling Dendrimers using Cu(I)-Catalyzed C−O Bond Formation

  摘要：

  The convergent synthesis of geometrically degradable dendrimers based on the 2,4-bis(hydroxymethyl)phenol subunit is presented. The key step of the synthetic scheme involves the CuI/3,4,7,8-tetramethyl-1,10-phenanthroline-catalyzed coupling of aryl iodides and alcohols. The synthesis and disassembly of these compounds is discussed.

  DOI：

  10.1021/ol102081q

文献信息

• Convergent Synthesis of Geometrically Disassembling Dendrimers using Cu(I)-Catalyzed C−O Bond Formation
  作者：Nathan W. Polaske、Michael L. Szalai、Charles S. Shanahan、Dominic V. McGrath

  DOI：10.1021/ol102081q

  日期：2010.11.5

  The convergent synthesis of geometrically degradable dendrimers based on the 2,4-bis(hydroxymethyl)phenol subunit is presented. The key step of the synthetic scheme involves the CuI/3,4,7,8-tetramethyl-1,10-phenanthroline-catalyzed coupling of aryl iodides and alcohols. The synthesis and disassembly of these compounds is discussed.