2-{[(2-{4-[5-(dimethylamino)pyrazolo[1,5-a]pyrimidin-3-yl]phenoxy}-5-pyrimidinyl)carbamoyl]amino}-N,N-dimethyl-4-(trifluoromethyl)benzenesulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-{[(2-{4-[5-(dimethylamino)pyrazolo[1,5-a]pyrimidin-3-yl]phenoxy}-5-pyrimidinyl)carbamoyl]amino}-N,N-dimethyl-4-(trifluoromethyl)benzenesulfonamide
• 英文别名: 1-[2-[4-[5-(Dimethylamino)pyrazolo[1,5-a]pyrimidin-3-yl]phenoxy]pyrimidin-5-yl]-3-[2-(dimethylsulfamoyl)-5-(trifluoromethyl)phenyl]urea；1-[2-[4-[5-(dimethylamino)pyrazolo[1,5-a]pyrimidin-3-yl]phenoxy]pyrimidin-5-yl]-3-[2-(dimethylsulfamoyl)-5-(trifluoromethyl)phenyl]urea
• 化学式: C₂₈H₂₆F₃N₉O₄S
• 分子量: 641.634
• InChiKey: AKQLFZBWPUZAGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  45
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  155
• 氢给体数：
  2
• 氢受体数：
  13

文献信息

• Trk-INHIBITING COMPOUND
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：US20160000783A1

  公开（公告）日：2016-01-07

  The present invention provides a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy for Trk-related diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I), wherein all symbols represent the same meanings as described in the specification, a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.

  本发明提供了一种药物，其中包含具有Trk抑制活性的化合物作为预防和/或治疗Trk相关疾病的活性成分，例如疼痛、瘙痒、下尿路功能障碍、哮喘、过敏性鼻炎、炎症性肠病或查加斯病。通式（I）所表示的化合物，其中所有符号都表示规范中描述的相同含义，其盐，N-氧化物，溶剂化物或前药是作为具有Trk抑制活性的药物成分在预防和/或治疗疼痛、瘙痒、下尿路功能障碍、哮喘、过敏性鼻炎、炎症性肠病或查加斯病等疾病中有用的。
• Trk-inhibiting compound
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：US10300060B2

  公开（公告）日：2019-05-28

  The present invention provides a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy for Trk-related diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I), wherein all symbols represent the same meanings as described in the specification, a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.

  本发明提供了一种含有具有Trk-抑制活性的化合物的药物，作为预防和/或治疗Trk相关疾病（如疼痛、瘙痒、下尿路功能障碍、哮喘、过敏性鼻炎、炎症性肠病或南美锥虫病）的活性成分。通式(I)（其中所有符号代表与说明书所述相同的含义）代表的化合物、其盐、其 N-氧化物、其溶解物或其原药可作为具有 Trk 抑制活性的药物成分，用于预防和/或治疗疼痛、瘙痒、下尿路功能障碍、哮喘、过敏性鼻炎、炎症性肠病或南美锥虫病等疾病。
• TRK-INHIBITING COMPOUND
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：US20160280684A1

  公开（公告）日：2016-09-29

  The present invention provides a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy for Trk-related diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I), wherein all symbols represent the same meanings as described in the specification, a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.
• US9463192B2
  申请人：——

  公开号：US9463192B2

  公开（公告）日：2016-10-11
• US9498453B2
  申请人：——

  公开号：US9498453B2

  公开（公告）日：2016-11-22