N-cyclopropyl-4-[6-(2,3-difluoro-4-methoxyphenoxy)-8-(oxan-2-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-2-methylbenzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-cyclopropyl-4-[6-(2,3-difluoro-4-methoxyphenoxy)-8-(oxan-2-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-2-methylbenzamide
• 化学式: C₃₀H₃₁F₂N₅O₄
• 分子量: 563.6
• InChiKey: XWOSFPCZWFNLAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  41
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  99
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• SUBSTITUTED IMIDAZOPYRIDAZINES
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：EP2961752A2

  公开（公告）日：2016-01-06
• [EN] SUBSTITUTED IMIDAZOPYRIDAZINES<br/>[FR] COMPOSÉS IMIDAZOPYRIDAZINES SUBSTITUÉS
  申请人：BAYER PHARMA AG

  公开号：WO2014131739A2

  公开（公告）日：2014-09-04

  The present invention relates to substituted imidazopyridazine compounds, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.