2-chloro-N-[1-phenyl-3-(4-propylphenyl)-1H-pyrazol-5-yl]acetamide | 882223-22-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-chloro-N-[1-phenyl-3-(4-propylphenyl)-1H-pyrazol-5-yl]acetamide
• 英文别名: 2-chloro-N-[2-phenyl-5-(4-propylphenyl)pyrazol-3-yl]acetamide
• CAS: 882223-22-5
• 化学式: C₂₀H₂₀ClN₃O
• mdl: MFCD03964572
• 分子量: 353.8
• InChiKey: QISZVXWVXQJFRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  46.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• METHODS AND COMPOUNDS FOR TARGETED AUTOPHAGY
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20190290778A1

  公开（公告）日：2019-09-26

  Provided herein, inter alia, are methods and compounds for targeted autophagy.

  本文提供了针对靶向自噬的方法和化合物。
• COVALENT TARGETING OF E3 LIGASES
  申请人：The Regents of the University of California

  公开号：US20210369731A1

  公开（公告）日：2021-12-02

  Disclosed herein, inter alia, are compositions and methods for targeting E3 ligases. In an aspect is a targeted protein degrader including 1) a targeted protein binder and 2) an E3 Ubiquitin ligase binder, wherein the E3 Ubiquitin ligase is human RNF4 or human RNF114. In an aspect is provided a pharmaceutical composition including a compound as described herein, including embodiments, and a pharmaceutically acceptable excipient.