5-Propan-2-yl-2-(trifluoromethyl)-1,3-oxazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-Propan-2-yl-2-(trifluoromethyl)-1,3-oxazole
• 英文别名: 5-propan-2-yl-2-(trifluoromethyl)-1,3-oxazole
• 化学式: C₇H₈F₃NO
• 分子量: 179.14
• InChiKey: BINKZJQCPDFTSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  26
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Bradykinin B2 receptor antagonists
  申请人：Pharvaris Netherlands B.V.

  公开号：US10836748B2

  公开（公告）日：2020-11-17

  The invention relates to a compound according to general formula (I), which acts as a bradykinin (BK) B2 receptor antagonist; to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament.

  本发明涉及一种通式（I）化合物，它可作为缓激肽（BK）B2 受体拮抗剂；涉及一种含有一种或多种本发明化合物的药物组合物；涉及一种含有至少一种本发明化合物和至少一种其它活性药物成分的复方制剂；还涉及所述化合物的用途，包括作为药物的用途。
• Sting agonist compounds and methods of use
  申请人：Mersana Therapeutics, Inc.

  公开号：US11155567B2

  公开（公告）日：2021-10-26

  The present disclosure relates to STING (Stimulator of Interferon Genes) agonist compounds, methods of making the compounds and their methods of use.

  本公开涉及 STING（干扰素基因刺激器）激动剂化合物、制造该化合物的方法及其使用方法。
• US20140256756A1
  申请人：——

  公开号：US20140256756A1

  公开（公告）日：2014-09-11
• SUBSTITUTED TRIAZINONE COMPOUND AND T-TYPE CALCIUM CHANNEL INHIBITOR
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US20160340322A1

  公开（公告）日：2016-11-24

  Disclosed is a novel triazinone compound with an inhibitory activity on a T-type voltage-dependent calcium channel, and is specifically useful for prevention or treatment of pain, chronic kidney disease and atrial fibrillation. A novel triazinone compound of Formula (I), wherein each substituent in the formula is defined in detail in the description, R 4 means a hydrogen atom, or a C 1-6 alkoxy group, etc., L 1 and L 2 each independently mean a single bond, or NR 2 , etc., L 3 means a C 1-6 alkylene group, etc., A means a C 6-14 aryl group or a 5 to 10-membered heteroaryl group which may be substituted, B means a C 3-11 cycloalkylene group, etc., D means a C 6-14 aryl amino group or a 5 to 10-membered heteroaryl group which may be substituted, etc., a tautomer of the compound, a pharmaceutically acceptable salt of the compound, or a solvate of the compound, the tautomer, or the pharmaceutically acceptable salt.
• NOVEL BRADYKININ B2 RECEPTOR ANTAGONISTS
  申请人：Pharvaris Netherlands B.V.

  公开号：US20200255405A1

  公开（公告）日：2020-08-13

  The invention relates to a compound according to general formula (I), which acts as a bradykinin (BK) B2 receptor antagonist; to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament.