N-(4-chloro-3-{6-methyl-1H-imidazo[4,5-b]pyridin-2-yl}phenyl)-2-hydroxy-2-[4-(trifluoromethyl)phenyl]acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(4-chloro-3-{6-methyl-1H-imidazo[4,5-b]pyridin-2-yl}phenyl)-2-hydroxy-2-[4-(trifluoromethyl)phenyl]acetamide
• 英文别名: N-[4-chloro-3-(6-methyl-1H-imidazo[4,5-b]pyridin-2-yl)phenyl]-2-hydroxy-2-[4-(trifluoromethyl)phenyl]acetamide
• 化学式: C₂₂H₁₆ClF₃N₄O₂
• 分子量: 460.843
• InChiKey: UVYGBQKQXSGVJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  90.9
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• US20140275013A1
  申请人：——

  公开号：US20140275013A1

  公开（公告）日：2014-09-18
• US9233961B2
  申请人：——

  公开号：US9233961B2

  公开（公告）日：2016-01-12
• [EN] COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES<br/>[FR] COMPOSÉS ET COMPOSITIONS POUR LE TRAITEMENT DE MALADIES PARASITAIRES
  申请人：IRM LLC

  公开号：WO2014151630A2

  公开（公告）日：2014-09-25

  The present invention is related to compounds of Formula A or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further relates to pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as Leishmaniasis, Human African Trypanosomiasis and Chagas disease.