Acetamide, N-[(2S)-3-[2-ethyl-6-methyl-4-[5-[2-(1-methylethyl)-4-pyridinyl]-1,2,4-oxadiazol-3-yl]phenoxy]-2-hydroxypropyl]-2-hydroxy-

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: Acetamide, N-[(2S)-3-[2-ethyl-6-methyl-4-[5-[2-(1-methylethyl)-4-pyridinyl]-1,2,4-oxadiazol-3-yl]phenoxy]-2-hydroxypropyl]-2-hydroxy-
• 英文别名: N-[3-[2-ethyl-6-methyl-4-[5-(2-propan-2-ylpyridin-4-yl)-1,2,4-oxadiazol-3-yl]phenoxy]-2-hydroxypropyl]-2-hydroxyacetamide
• 化学式: C₂₄H₃₀N₄O₅
• 分子量: 454.5
• InChiKey: BUMUZYJYGCXMOQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  131
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• [EN] PYRIDIN-4-YL DERIVATIVES<br/>[FR] DÉRIVÉS DE PYRIDIN-4-YLE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2014141171A1

  公开（公告）日：2014-09-18

  The invention relates to compounds of the Formula (I), Formula (I) wherein R1 and R2 are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

  该发明涉及公式(I)的化合物，其中R1和R2如描述中所述，它们的制备以及它们作为药用活性化合物的用途。这些化合物特别作为免疫调节剂。
• PYRIDIN-4-YL DERIVATIVES
  申请人：ACTELION PHARMACEUTICALS LTD.

  公开号：US20160031866A1

  公开（公告）日：2016-02-04

  The invention relates to compounds of the Formula (I), Formula (I) wherein R 1 and R 2 are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

  该发明涉及公式（I）的化合物，其中R1和R2如说明书中所述，它们的制备以及它们作为药物活性化合物的用途。所述化合物特别作为免疫调节剂。
• US9617250B2
  申请人：——

  公开号：US9617250B2

  公开（公告）日：2017-04-11