9-bromo-2-diethylamino-5,11-dimethyl-6H-pyrimido[5,4-b]carbazol-4(3H)-one | 1204175-70-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 9-bromo-2-diethylamino-5,11-dimethyl-6H-pyrimido[5,4-b]carbazol-4(3H)-one
• 英文别名: 9-Bromo-2-(diethylamino)-5,11-dimethyl-3,6-dihydropyrimido[5,4-b]carbazol-4-one；9-bromo-2-(diethylamino)-5,11-dimethyl-3,6-dihydropyrimido[5,4-b]carbazol-4-one
• CAS: 1204175-70-1
• 化学式: C₂₀H₂₁BrN₄O
• 分子量: 413.317
• InChiKey: RXLSGPDAHOHVKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  60.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 9-bromo-2-diethylamino-5,11-dimethyl-6H-pyrimido[5,4-b]carbazol-4(3H)-one
  参考文献：
  名称：

  A rapid and versatile synthesis of novel pyrimido[5,4-b]carbazoles

  摘要：

  A one-pot synthesis of 2-dialkylamino-5,11-dimethyl-6H-pyrimido[5,4-b]carbazol-4(3H)-ones, as new ellipticine analogs, starting from aminocarbazole derivatives is reported. This method allowed us to prepare a library of potentially useful compounds in the pharmaceutical field. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.10.025

文献信息

• A rapid and versatile synthesis of novel pyrimido[5,4-b]carbazoles
  作者：Anna Caruso、Jean-Charles Lancelot、Hussein El-Kashef、Maria Stefania Sinicropi、Rémi Legay、Aurélien Lesnard、Sylvain Rault

  DOI：10.1016/j.tet.2009.10.025

  日期：2009.12

  A one-pot synthesis of 2-dialkylamino-5,11-dimethyl-6H-pyrimido[5,4-b]carbazol-4(3H)-ones, as new ellipticine analogs, starting from aminocarbazole derivatives is reported. This method allowed us to prepare a library of potentially useful compounds in the pharmaceutical field. (C) 2009 Elsevier Ltd. All rights reserved.