1-(2-methylphenyl)-5-({[3-(trifluoromethyl)phenyl]methyl}sulfanyl)-1H-1,2,3,4-tetrazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(2-methylphenyl)-5-({[3-(trifluoromethyl)phenyl]methyl}sulfanyl)-1H-1,2,3,4-tetrazole
• 英文别名: 1-(2-methylphenyl)-5-[[3-(trifluoromethyl)phenyl]methylsulfanyl]tetrazole
• 化学式: C₁₆H₁₃F₃N₄S
• 分子量: 350.4
• InChiKey: AXVCBEDZGGQWGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  68.9
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• [EN] BENZYLTHIOTETRAZOLE INHIBITORS OF STORE OPERATED CALCIUM RELEASE<br/>[FR] INHIBITEURS BENZYLTHIOTÉTRAZOLE DE LIBÉRATION DE CALCIUM CAPACITIF
  申请人：CALCIMEDICA INC

  公开号：WO2010034003A2

  公开（公告）日：2010-03-25

  Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases, disorders or conditions that would benefit from inhibition of SOC channel activity.