2-[[4-Amino-3-(3-fluoro-5-hydroxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-methyl-3-[[2-(trifluoromethyl)phenyl]methyl]quinazolin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[[4-Amino-3-(3-fluoro-5-hydroxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-methyl-3-[[2-(trifluoromethyl)phenyl]methyl]quinazolin-4-one
• 英文别名: 2-[[4-amino-3-(3-fluoro-5-hydroxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-methyl-3-[[2-(trifluoromethyl)phenyl]methyl]quinazolin-4-one
• 化学式: C₂₉H₂₁F₄N₇O₂
• 分子量: 575.5
• InChiKey: POACMKYNRJBEEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  42
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• 2-((4-AMINO-3-(3-FLUORO-5-HYDROXYPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1 -YL)METHYL)-3-(2-(TRIFLUOROMETHYL)BENZYL) QUINAZOLIN-4(3H)-ONE DERIVATIVES AND THEIR USE AS PHOSPHOINOSITIDE 3-KINASE INHIBITORS
  申请人：RESPIVERT LIMITED

  公开号：US20160039826A1

  公开（公告）日：2016-02-11

  The present invention relates inter alia to a compound of formula (I) and to compositions comprising the same and to the use of the compounds and to compositions of the compounds in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making the said compounds.

  本发明涉及公式（I）的化合物，以及包含该化合物的组合物，以及化合物和组合物在治疗中的使用，例如在炎症性疾病的治疗中，特别是呼吸系统炎症性疾病的治疗中。本发明还涉及制备所述化合物的方法。
• Phosphoinositide 3-Kinase Inhibitors
  申请人：Respivert Ltd.

  公开号：US20160090389A1

  公开（公告）日：2016-03-31

  The present invention relates inter alia to a compound of formula (I) and to compositions comprising the same and to the use of the compounds and to compositions of the compounds in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making the said compounds.

  本发明涉及公式（I）的化合物，以及包含该化合物的组合物，以及该化合物和该化合物的组合物在治疗中的用途，例如在治疗炎症性疾病，特别是呼吸道炎症性疾病方面的用途。本发明还涉及制备所述化合物的方法。
• US20140274980A1
  申请人：——

  公开号：US20140274980A1

  公开（公告）日：2014-09-18
• 2-((4-AMINO-3-(3-FLUORO-5-HYDROXYPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1 -YL)METHYL)-3-(2-(TRIFLUORO-MET HYL)BENZYL)QUINAZOLIN-4(3H)-ONE DERIVATIVES AND THEIR USE AS PHOSPHOINOSITIDE 3-KINASE INHIBITORS
  申请人：RESPIVERT LTD.

  公开号：US20170334919A1

  公开（公告）日：2017-11-23

  The present invention relates inter alia to a compound of formula (I) and to compositions comprising the same and to the use of the compounds and to compositions of the compounds in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making the said compounds.
• US9227977B2
  申请人：——

  公开号：US9227977B2

  公开（公告）日：2016-01-05