1-Methyl-2-phenyl-5-(pyridin-2-ylmethyl)pyrazolo[4,3-c]pyridine-3,6-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-Methyl-2-phenyl-5-(pyridin-2-ylmethyl)pyrazolo[4,3-c]pyridine-3,6-dione
• 英文别名: 1-methyl-2-phenyl-5-(pyridin-2-ylmethyl)pyrazolo[4,3-c]pyridine-3,6-dione
• 化学式: C₁₉H₁₆N₄O₂
• 分子量: 332.4
• InChiKey: WCBMEFQIAIOPLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  56.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• METHODS OF PRESERVING AND PROTECTING PANCREATIC BETA CELLS AND TREATING OR PREVENTING DIABETES BY INHIBITING NOX-1
  申请人：EASTERN VIRGINIA MEDICAL SCHOOL

  公开号：US20160010061A1

  公开（公告）日：2016-01-14

  Methods of preserving and/or protecting pancreatic beta cells by inhibiting NOX-1. In a further aspect, NOX-1 inhibitors are administered to a subject in order to preserve and/or protect beta cells in the prevention or treatment of diabetes. NOX-1 inhibitors are also disclosed; The method can be used to preserve beta cell/islet survival in vitro, or in vivo in cells exposed to stressful stimuli including but not limited to inflammation, inflammatory cytokines, high glucose, or elevated free fatty acids.
• US9688960B2
  申请人：——

  公开号：US9688960B2

  公开（公告）日：2017-06-27
• US9914910B2
  申请人：——

  公开号：US9914910B2

  公开（公告）日：2018-03-13
• [EN] METHODS OF PRESERVING AND PROTECTING PANCREATIC BETA CELLS AND TREATING OR PREVENTING DIABETES BY INHIBITING NOX-1<br/>[FR] PROCÉDÉS DE PRÉSERVATION ET DE PROTECTION DES CELLULES BÊTA PANCRÉATIQUES ET DE TRAITEMENT OU DE PRÉVENTION DU DIABÈTE EN INHIBANT NOX-1
  申请人：EASTERN VIRGINIA MED SCHOOL

  公开号：WO2014153227A1

  公开（公告）日：2014-09-25

  Methods of preserving and/or protecting pancreatic beta cells by inhibiting NOX-1. In a further aspect, NOX-1 inhibitors are administered to a subject in order to preserve and/or protect beta cells in the prevention or treatment of diabetes. NOX-1 inhibitors are also disclosed; The method can be used to preserve beta cell/ islet survival in vitro, or in vivo in cells exposed to stressful stimuli including but not limited to inflammation, inflammatory cytokines, high glucose, or elevated free fatty acids.