[1-[[2-(4-Cyanophenyl)pyrazol-3-yl]methyl-methylamino]-3,3-dimethylbutan-2-yl] carbamate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [1-[[2-(4-Cyanophenyl)pyrazol-3-yl]methyl-methylamino]-3,3-dimethylbutan-2-yl] carbamate
• 英文别名: [1-[[2-(4-cyanophenyl)pyrazol-3-yl]methyl-methylamino]-3,3-dimethylbutan-2-yl] carbamate
• 化学式: C₁₉H₂₅N₅O₂
• 分子量: 355.4
• InChiKey: SDVLSQWDRJCZQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  97.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF
  申请人：EPIZYME, INC.

  公开号：US20160031839A1

  公开（公告）日：2016-02-04

  Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.

  本文描述了公式（I）的化合物及其药学上可接受的盐和药物组成物。本发明的化合物对于抑制精氨酸甲基转移酶活性是有用的。本文还描述了使用这些化合物治疗精氨酸甲基转移酶介导的疾病的方法。
• [EN] ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE L'ARGININE MÉTHYLTRANSFÉRASE ET UTILISATIONS DE CEUX-CI
  申请人：EPIZYME INC

  公开号：WO2014153100A2

  公开（公告）日：2014-09-25

  Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.