DBM 1285 dihydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: DBM 1285 dihydrochloride
• 英文别名: N-cyclopropyl-4-[4-(4-fluorophenyl)-2-piperidin-4-yl-1,3-thiazol-5-yl]pyrimidin-2-amine;dihydrochloride
• 化学式: C21H24Cl2FN5S
• 分子量: 468.4
• InChiKey: ANQWETXPBPZVOF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.29
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  91
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• TGFß SIGNALING INDEPENDENT NAÏVE INDUCED PLURIPOTENT STEM CELLS, METHODS OF MAKING AND USE
  申请人：Hong Guan Ltd.

  公开号：EP3198004A1

  公开（公告）日：2017-08-02
• MATURE AIRWAY ORGANOIDS, METHODS OF MAKING AND USES THEREOF
  申请人：THE UNIVERSITY OF HONG KONG

  公开号：US20210207081A1

  公开（公告）日：2021-07-08

  Provided are methods for generating 2D and 3D differentiated airway organoids, 2D and 3D differentiated airway organoids which are generated by the methods and uses for the 2D and 3D differentiated airway organoids.
• [EN] TGFβ SIGNALING INDEPENDENT NAÏVE INDUCED PLURIPOTENT STEM CELLS, METHODS OF MAKING AND USE<br/>[FR] CELLULES SOUCHES PLURIPOTENTES INDUITES NAÏVES INDÉPENDANTES DE LA SIGNALISATION TGFSS, PROCÉDÉS DE PRODUCTION ET UTILISATION
  申请人：HONG GUAN LTD

  公开号：WO2016045550A1

  公开（公告）日：2016-03-31

  Provided is a cocktail of factors for converting/reprogramming non-naïve pluripotent stem cells into TGFβ signaling-independent (TSI) naïve induced pluripotent stem cells (iPSCs). Also provided are methods for reprograming a non-naïve PSC into a TSI naïve iPSC by contacting the cell to be reprogrammed with effective amounts of compounds for a sufficient period of time to reprogram the cell into a TSI naïve iPSC.