5H-Dibenzo(b,E)(1,4)diazepine-8-carboxamide, N-(2-(diethylamino)ethyl)-10,11-dihydro-11-oxo- | 440120-42-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 5H-Dibenzo(b,E)(1,4)diazepine-8-carboxamide, N-(2-(diethylamino)ethyl)-10,11-dihydro-11-oxo-
• 英文别名: N-[2-(diethylamino)ethyl]-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepine-3-carboxamide
• CAS: 440120-42-3
• 化学式: C₂₀H₂₄N₄O₂
• 分子量: 352.4
• InChiKey: LAHXVXSEXYSIOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  73.5
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Compositions and methods for modulating poly(ADP-ribose) polymerase activity
  申请人：Kazantsev G. Aleksey

  公开号：US20070105835A1

  公开（公告）日：2007-05-10

  The present invention is based, in part, on assays we conducted that revealed compounds that modulate (e.g., inhibit) PARP-1 and are therefore useful in treating or preventing diseases characterized by abnormal PARP-1 activity (e.g., undesirable PARP-1 activity).
• COMPOSITIONS AND METHODS FOR MODULATING POLY(ADP-RIBOSE) POLYMERASE ACTIVITY
  申请人：Kazantsev Aleksey G.

  公开号：US20100069372A1

  公开（公告）日：2010-03-18

  The present invention is based, in part, on assays we conducted that revealed compounds that modulate (e.g., inhibit) PARP-1 and are therefore useful in treating or preventing diseases characterized by abnormal PARP-1 activity (e.g., undesirable PARP-1 activity).
• [EN] COMPOSITIONS AND METHODS FOR MODULATING POLY (ADP-RIBOSE) POLYMERASE ACTIVITY<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE MODULATION DE L'ACTIVITÉ DE LA POLY(ADP-RIBOSE) POLYMÉRASE
  申请人：GEN HOSPITAL CORP

  公开号：WO2007056388A9

  公开（公告）日：2007-08-30

  [EN] The present invention is based, in part, on assays we conducted that revealed compounds that modulate (e.g., inhibit) PARP-1 and are therefore useful in treating or preventing diseases characterized by abnormal PARP-1 activity (e.g., undesirable PARP 1 activity).
  [FR] La présente invention est basée, en partie, sur des tests que nous avons menés qui ont révélé des composés qui modulent (par ex., inhibent) la PARP-1 et qui sont donc utiles dans le traitement ou la prévention de maladies caractérisées par une activité anormale de la PARP-1 (par ex., une activité de la PARP-1 indésirable).