3-hydroxybutyrate | 151-03-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 3-hydroxybutyrate
• 英文别名: β-hydroxybutyrate；beta-hydroxybutyrate；BHB；3-Hydroxybutyrat；D-3-hydroxybutyrate；3-hydroxybutanoate
• CAS: 151-03-1
• 化学式: C₄H₇O₃
• 分子量: 103.098
• InChiKey: WHBMMWSBFZVSSR-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  60.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-hydroxybutyrate 生成 acetoacetic acid anion
  参考文献：
  名称：

  PALLESCHI, G.;RATHORE, H. S.;MASCINI, M., ANAL. CHIM. ACTA, 209,(1988) N 1-2, 223-230

  摘要：

  DOI：
• 作为产物：
  描述：

  乙酰乙酸锂 在 Rhodobacter capsulatus SB₁₀₀₃ 3-hydroxybutyrate dehydrogenase 、 还原型辅酶Ⅰ 作用下， 以 aq. buffer 为溶剂， 生成 3-hydroxybutyrate
  参考文献：
  名称：

  Visible-light-driven 3-hydroxybutyrate production from acetone and low concentrations of CO₂ with a system of hybridized photocatalytic NADH regeneration and multi-biocatalysts

  摘要：

  利用杂化光催化 NADH 再生和多生物催化剂系统，首次开发了从低浓度 CO2 和废丙酮中生产 3- 羟基丁酸的可见光驱动技术。

  DOI：

  10.1039/d3gc00247k

文献信息

• Process for acyl-transfer enzyme reactions with acyl-coenzyme a
  申请人：Kamachi Motoaki

  公开号：US20060148048A1

  公开（公告）日：2006-07-06

  The present invention relates to a method for acyltransferase reaction in which an acyl group of acyl coenzyme A is transferred to an acyl group receptor characterized in that the reaction is carried out by production and/or reproduction of acyl coenzyme A from coenzyme A in a reaction system by a chemical thioester exchange reaction with acylthioester. The present invention, wherein expensive acyl CoA is reproduced nonenzymatically in a reaction system, enables to continuously carry out acyltransferase reaction only by putting a small amount of acyl CoA with a donor and a receptor of an acyl group into a system. Accordingly, the method of the present invention can be applied to an industrial production method of various kinds of compounds including useful biological molecules and synthesis of polylmers such as polyester.

  本发明涉及一种酰基转移酶反应的方法，其中酰辅酶A的酰基被转移给酰基受体，其特征在于该反应是通过在反应体系中通过与酰硫酯的化学硫酯交换反应从辅酶A中生产和/或再生酰基辅酶A而进行的。本发明通过在反应体系中非酶地再生昂贵的酰基辅酶A，仅需将少量酰基辅酶A与酰基供体和受体一起放入系统中即可连续进行酰基转移酶反应。因此，本发明的方法可应用于各种化合物的工业生产方法，包括有用的生物分子和聚合物合成，如聚酯的合成。
• METHOD FOR ACYLTRANSFERASE REACTION USING ACYL COENZYME A
  申请人：KAMACHI Motoaki

  公开号：US20090111153A1

  公开（公告）日：2009-04-30

  The present invention relates to a method for acyltransferase reaction in which an acyl group of acyl coenzyme A is transferred to an acyl group receptor characterized in that the reaction is carried out by production and/or reproduction of acyl coenzyme A from coenzyme A in a reaction system by a chemical thioester exchange reaction with acylthioester. The present invention, wherein expensive acyl CoA is reproduced nonenzymatically in a reaction system, enables to continuously carry out acyltransferase reaction only by putting a small amount of acyl CoA with a donor and a receptor of an acyl group into a system. Accordingly, the method of the present invention can be applied to an industrial production method of various kinds of compounds including useful biological molecules and synthesis of polymers such as polyester.

  本发明涉及一种酰基转移酶反应的方法，其中酰辅酶A的酰基被转移给酰基受体，其特征在于该反应是通过在反应体系中通过与酰硫酯的化学硫酯交换反应产生和/或再生酰辅酶A来进行的。本发明中，昂贵的酰辅酶A是在反应体系中非酶催化再生的，只需将少量酰辅酶A与酰基供体和受体一起加入到反应体系中即可连续进行酰基转移酶反应。因此，本发明的方法可以应用于各种化合物的工业生产方法，包括有用的生物分子和聚酯等聚合物的合成。
• COPOLYMER COMPRISING 4-HYDROXYBUTYRATE UNIT AND LACTATE UNIT AND ITS MANUFACTURING METHOD
  申请人：Park Si-Jae

  公开号：US20100222545A1

  公开（公告）日：2010-09-02

  The present invention relates to a copolymer comprising 4-hydroxybutyrate monomer unit and lactate monomer unit, a copolymer 4-hydroxybutyrate monomer unit, lactate monomer unit and 3-hydroxyalkanoate, or their preparing method. More specifically, the present invention relates to a method for preparing a copolymer comprising lactate monomer; 4-hydroxybutyrate monomer; and optionally 3-hydroxyalkanoate, wherein the method comprises culturing a cell or plant comprising the gene of enzyme converting lactate and 3-hydroxyalkanoate into lactyl-CoA and 3-hydroxyalkanoyl-CoA, respectively, phosphotransbutylase gene, butyrate kinase gene and polyhydroxyalkanoate synthase gene together, and the copolymer made by the method. The copolymer of the present invention is a biodegradable polymer being able to be usefully used instead of conventional synthetic plastic, and the copolymer can be used for medical use.

  本发明涉及一种共聚物，其包含4-羟基丁酸单体单元和乳酸单体单元，或者包含4-羟基丁酸单体单元、乳酸单体单元和3-羟基烷酸单体单元的共聚物，以及它们的制备方法。更具体地说，本发明涉及一种制备包含乳酸单体单元、4-羟基丁酸单体单元和可选的3-羟基烷酸单体单元的共聚物的方法，其中该方法包括培养含有将乳酸和3-羟基烷酸转化为乳酰辅酶A和3-羟基烷酰辅酶A的酶基因、磷酸丁醇转移酶基因、丁酸激酶基因和聚羟基烷酸合酶基因的细胞或植物，并由该方法制备的共聚物。本发明的共聚物是一种可生物降解的聚合物，能够代替传统的合成塑料有用地使用，可用于医疗用途。
• Method for acyltransferase reaction using acyl coenzyme A
  申请人：Showa Denko K.K.

  公开号：US07476521B2

  公开（公告）日：2009-01-13

  The present invention relates to a method for acyltransferase reaction in which an acyl group of acyl coenzyme A is transferred to an acyl group receptor characterized in that the reaction is carried out by production and/or reproduction of acyl coenzyme A from coenzyme A in a reaction system by a chemical thioester exchange reaction with acylthioester. The present invention, wherein expensive acyl CoA is reproduced nonenzymatically in a reaction system, enables to continuously carry out acyltransferase reaction only by putting a small amount of acyl CoA with a donor and a receptor of an acyl group into a system. Accordingly, the method of the present invention can be applied to an industrial production method of various kinds of compounds including useful biological molecules and synthesis of polylmers such as polyester.

  本发明涉及一种酰基转移酶反应的方法，其中酰辅酶A的酰基转移到酰基受体上，其特征在于通过化学硫酯交换反应从辅酶A中生产和/或再生酰基辅酶A，从而在反应系统中进行反应。本发明通过在反应系统中非酶法再生昂贵的酰基辅酶A，只需将少量酰基辅酶A与供体和受体的酰基放入系统中即可连续进行酰基转移酶反应。因此，本发明的方法可应用于各种化合物的工业生产方法，包括有用的生物分子和聚合物的合成。
• Copolymer comprising 4-hydroxybutyrate unit and lactate unit and its manufacturing method
  申请人：Park Si-Jae

  公开号：US08383379B2

  公开（公告）日：2013-02-26

  The present invention relates to a copolymer comprising 4-hydroxybutyrate monomer unit and lactate monomer unit, a copolymer 4-hydroxybutyrate monomer unit, lactate monomer unit and 3-hydroxyalkanoate, or their preparing method. More specifically, the present invention relates to a method for preparing a copolymer comprising lactate monomer; 4-hydroxybutyrate monomer; and optionally 3-hydroxyalkanoate, wherein the method comprises culturing a cell or plant comprising the gene of enzyme converting lactate and 3-hydroxyalkanoate into lactyl-CoA and 3-hydroxyalkanoyl-CoA, respectively, phosphotransbutylase gene, butyrate kinase gene and polyhydroxyalkanoate synthase gene together, and the copolymer made by the method. The copolymer of the present invention is a biodegradable polymer being able to be usefully used instead of conventional synthetic plastic, and the copolymer can be used for medical use.

  本发明涉及一种共聚物，包括4-羟基丁酸单体单元和乳酸单体单元，一种共聚物4-羟基丁酸单体单元，乳酸单体单元和3-羟基烷酸单体单元，或其制备方法。更具体地，本发明涉及一种制备包括乳酸单体单元；4-羟基丁酸单体单元；以及可选的3-羟基烷酸单体单元的共聚物的方法，其中该方法包括培养包含将乳酸和3-羟基烷酸转化为乳酰辅酶A和3-羟基烷酰辅酶A的酶基因，磷酸丁酰转移酶基因，丁酸激酶基因和聚羟基烷酸合成酶基因的细胞或植物，并通过该方法制备的共聚物。本发明的共聚物是一种可生物降解的聚合物，可以代替传统的合成塑料有用地使用，并可用于医疗用途。