Acetic acid [3-phenyl-prop-(E)-ylidene]-hydrazide | 188262-98-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Acetic acid [3-phenyl-prop-(E)-ylidene]-hydrazide
• 英文别名: N-(3-phenylpropylideneamino)acetamide
• CAS: 188262-98-8
• 化学式: C₁₁H₁₄N₂O
• 分子量: 190.245
• InChiKey: OUUSBODFYWUMFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Acetic acid [3-phenyl-prop-(E)-ylidene]-hydrazide 在 palladium on activated charcoal N-甲基吗啉 、 氢气 、 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 作用下， 以 四氢呋喃 、 乙醚 、 N,N-二甲基甲酰胺 为溶剂， 25.0 ℃ 、206.84 kPa 条件下， 生成
  参考文献：
  名称：

  Synthesis and biological activity of P2–P4 azapeptidomimetic P1-argininal and P1-ketoargininamide derivatives: a novel class of serine protease inhibitors

  摘要：

  Molecular modeling and topographic considerations of the thrombin-specific sequences Boc-Asp-Pro-Arg-TS or Ac-d-Phe-Pro-Arg-TS (TS = transition state analog electrophilic center) and related scaffolds led to the design of novel P-2-P-4-azapeptidomimetic P-1-argininal and P-1-ketoargininamide derivatives (3a-j). The synthesis and biological activity of these potential serine protease inhibitors are presented. (C) 1997, Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00005-x
• 作为产物：
  描述：

  苯丙醛 、 乙酰肼 以 二氯甲烷 为溶剂， 生成 Acetic acid [3-phenyl-prop-(E)-ylidene]-hydrazide
  参考文献：
  名称：

  Photocatalytic Carbosulfonylation/Cyclization of N-Homoallyl and N-Allyl Aldehyde Hydrazones toward Sulfonylated Tetrahydropyridazines and Dihydropyrazoles

  摘要：

  DOI：

  10.1021/acs.orglett.3c03733

文献信息

• Synthesis and biological activity of P2–P4 azapeptidomimetic P1-argininal and P1-ketoargininamide derivatives: a novel class of serine protease inhibitors
  作者：J.Edward Semple、David C. Rowley、Terence K. Brunck、William C. Ripka

  DOI：10.1016/s0960-894x(97)00005-x

  日期：1997.2

  Molecular modeling and topographic considerations of the thrombin-specific sequences Boc-Asp-Pro-Arg-TS or Ac-d-Phe-Pro-Arg-TS (TS = transition state analog electrophilic center) and related scaffolds led to the design of novel P-2-P-4-azapeptidomimetic P-1-argininal and P-1-ketoargininamide derivatives (3a-j). The synthesis and biological activity of these potential serine protease inhibitors are presented. (C) 1997, Elsevier Science Ltd.
• Photocatalytic Carbosulfonylation/Cyclization of <i>N</i>-Homoallyl and <i>N</i>-Allyl Aldehyde Hydrazones toward Sulfonylated Tetrahydropyridazines and Dihydropyrazoles
  作者：Yechun Wu、Xian Wu、Lingli Liu、Jin-Tao Yu、Changduo Pan

  DOI：10.1021/acs.orglett.3c03733

  日期：2024.1.12