4-Methyl-5-thiophen-2-yl-2H-pyrazole-3-carboxylic acid | 890621-27-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-Methyl-5-thiophen-2-yl-2H-pyrazole-3-carboxylic acid
• 英文别名: 4-methyl-5-thiophen-2-yl-1H-pyrazole-3-carboxylic acid
• CAS: 890621-27-9
• 化学式: C₉H₈N₂O₂S
• mdl: MFCD20356310
• 分子量: 208.24
• InChiKey: RZFZFQSJPCUVII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.111
• 拓扑面积：
  94.2
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 危险等级：
  IRRITANT

文献信息

• LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY
  申请人：Graffinity Pharmaceuticals GmbH

  公开号：EP2601208A2

  公开（公告）日：2013-06-12
• [EN] LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY<br/>[FR] LIGANDS POUR LA PURIFICATION D'ANTICORPS ET DE PROTÉINE DE FUSION À FC PAR CHROMATOGRAPHIE D'AFFINITÉ
  申请人：GRAFFINITY PHARMACEUTICALS GMBH

  公开号：WO2012017021A2

  公开（公告）日：2012-02-09

  The present invention relates to the use for affinity purification of an antibody or an fragment of an antibody, of a ligand-substituted matrix comprising a support material and at least one ligand covalently bonded to the support material, the ligand being represented by formula (I) wherein Sp is a spacer group; v is 0 or 1; Am is an amide group -NR1-C(O)-, and wherein either NR1 is attached to Ar1 and C(O)- is attached to Ar2, or -C(O)- is attached to Ar1 and NR1 is attached to Ar2; and R1 is hydrogen or C1 to C4 alkyl, preferably hydrogen or methyl; and more preferably hydrogen; Ar1 is a divalent 5- or 6-membered substituted or unsubstituted aromatic ring; Ar2 is 5- or 6-membered heterocyclic aromatic ring which is (a) attached to a further 5- or 6-membered aromatic ring via a single bond; or (b) fused to a further 5- or 6-membered aromatic ring as part of a multicyclic ring system; or (c) attached to at least one substituent selected from C1 to C4 alkyl; C2 to C4 alkenyl; C2 to C4 alkynyl; a halogen; C1 to C4 haloalkyl; hydroxyl-substituted C1 to C4 alkyl; C1 to C4 alkoxy; hydroxyl-substituted C1 to C4 alkoxy; C1 to C4 alkylamino; C1 to C4 alkylthio; and combinations thereof.