5-苯基四唑-2-基乙酸酰胺 | 25468-24-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 5-苯基四唑-2-基乙酸酰胺
• 英文名称: 5-phenyltetrazol-2-ylethanoic acid amide
• 英文别名: 2-(5-phenyl-2H-tetrazol-2-yl)acetamide；5-phenyl-2-tetrazolylacetic acid amide；(5-phenyltetrazol-2-yl)acetamide；5-phenyl-2-tetrazolylacetamide；2-(5-phenyl-tetrazol-2-yl)-acetamide；2-(5-phenyltetrazol-2-yl)acetamide
• CAS: 25468-24-0
• 化学式: C₉H₉N₅O
• mdl: MFCD02047949
• 分子量: 203.203
• InChiKey: SFMRLZQXQSMOJK-UHFFFAOYSA-N

物化性质

• 熔点：
  186-186.5 °C(Solv: water (7732-18-5); ethanol (64-17-5))
• 沸点：
  482.9±47.0 °C(Predicted)
• 密度：
  1.45±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.111
• 拓扑面积：
  86.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-苯基四唑-2-基乙酸酰胺 在 sodium hydroxide 作用下， 反应 3.0h， 以93%的产率得到(5-苯基-2-四唑)-乙酸
  参考文献：
  名称：

  摘要：

  DOI：

  10.1023/a:1020933900167
• 作为产物：
  描述：

  2-(5-苯基-2H-1,2,3,4-四唑-2-基)-乙酸乙酯 在 氨 作用下， 以 甲醇 为溶剂， 以57%的产率得到5-苯基四唑-2-基乙酸酰胺
  参考文献：
  名称：

  5-苯基-2-四唑基乙酸乙酯的氨解

  摘要：

  DOI：

  10.1023/a:1011909127876

文献信息

• 신규 N-아실유레아 유도체 및 이를 함유하는 심혈관질환의 예방 또는 치료용 조성물
  申请人：Korea University Research and Business Foundation 고려대학교 산학협력단(220040170680) BRN ▼209-82-08298

  公开号：KR101691954B1

  公开（公告）日：2017-01-02

  본 발명은 신규 N-아실유레아 유도체 및 이의 심혈관질환의 치료 또는 예방 용도에 관한 것으로, 더욱 자세하게는 신규 N-아실유레아 유도체, 상기 N-acylurea 유도체를 유효성분으로 함유하는 심혈관질환의 예방 또는 치료용 약학적 조성물 및 N-아실유레아 유도체의 제조방법에 관한 것으로, 본 발명에 따른 N-acylurea 유도체는 세포내 기질 (intracellular matrix)의 탈린 작용을 억제하여 혈소판 응집을 저해할 수 있으므로 심혈관질환의 예방 또는 치료에 유용하게 사용할 수 있다.

  该专利涉及新型N-酰基脲衍生物及其在心血管疾病的治疗或预防中的用途，更具体地说，涉及新型N-酰基脲衍生物，包含上述N-酰基脲衍生物作为有效成分的用于心血管疾病预防或治疗的药学组合物，以及关于N-酰基脲衍生物的制备方法，根据本发明的N-酰基脲衍生物能够抑制细胞内基质的塔林作用，从而可以有效用于心血管疾病的预防或治疗。
• Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages
  申请人：Michelet Jean-Francois

  公开号：US20060034786A1

  公开（公告）日：2006-02-16

  Inhibitors of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), for example tetrazole, styrylpyrazole, phenylfuran, phenylthiophene, phenylpyrrazole, pyrazolecarboxamide, 2-thioacetamide and azo compounds, are useful for promoting or stimulating pigmentation of the skin and/or skin appendages and/or for preventing and/or for limiting depigmentation and/or whitening of the skin and/or skin appendages, notably for preventing and/or limiting canities.

  15-羟基前列腺素脱氢酶（15-PGDH）的抑制剂，例如四唑、苯基吡唑、苯基呋喃、苯基噻吩、苯基吡唑、吡唑羧酰胺、2-硫代乙酰胺和偶氮化合物，可用于促进或刺激皮肤和/或皮肤附属物的色素沉淀和/或预防和/或限制皮肤和/或皮肤附属物的脱色和/或变白，特别是用于预防和/或限制白发。
• INHIBITORS OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE FOR STIMULATING PIGMENTATION OF THE SKIN OR SKIN APPENDAGES
  申请人：MICHELET JEAN-FRANCOIS

  公开号：US20110014250A1

  公开（公告）日：2011-01-20

  Inhibitors of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), for example tetrazole, styrylpyrazole, phenylfuran, phenylthiophene, phenylpyrrazole, pyrazolecarboxamide, 2-thioacetamide and azo compounds, are useful for promoting or stimulating pigmentation of the skin and/or skin appendages and/or for preventing and/or for limiting depigmentation and/or whitening of the skin and/or skin appendages, notably for preventing and/or limiting canities.

  15-羟基前列腺素脱氢酶（15-PGDH）的抑制剂，例如四唑、苯乙烯吡唑、苯并呋喃、苯并硫吩、苯并吡唑、吡唑羧酰胺、2-硫代乙酰胺和偶氮化合物，可用于促进或刺激皮肤和/或皮肤附属物的色素沉着，或预防和/或限制皮肤和/或皮肤附属物的脱色和/或变白，特别是预防和/或限制白发。
• Synthesis, Structure, and Antiproliferative Activity of trans-Palladium(II) Complexes with Tetrazol-2-ylacetic Acid Derivatives
  作者：E. A. Popova、O. V. Mikolaichuk、A. V. Protas、A. V. Mukhametshina、G. K. Ovsepyan、G. L. Starova、R. V. Suezov、A. V. Fonin、R. E. Trifonov

  DOI：10.1134/s1070363218110178

  日期：2018.11

  A series of trans-palladium(II) complexes (trans-[PdCl2L2], L = ethyl 5-R-2H-tetrazol-2-ylacetate, 5-R-2H-tetrazol-2-ylacetamides, R = Me, Ph) has been synthesized, and their structure has been proved by 1H and 13C–1H} NMR and high-resolution mass spectra and X-ray analysis. Antiproliferative activity of the synthesized complexes has been determined, and the mechanism of their interaction with DNA

  一系列反式钯（II）配合物（反式[PdCl 2 L 2 ]，L = 5-R-2 H-四唑-2-基乙酸乙酯，5-R-2 H-四唑-2-基乙酰胺，R = Me，Ph）已合成，其结构已通过1 H和13 C– 1 H} NMR，高分辨率质谱和X射线分析证明。已经确定了合成复合物的抗增殖活性，并通过紫外和CD光谱研究了它们与DNA的相互作用机理。
• Cosmetic composition, method of cosmetic treatment and preparation of a composition for promoting the growth and/or preventing or delaying the loss of hair
  申请人：SOCIETE L'OREAL S.A.

  公开号：US20040052760A1

  公开（公告）日：2004-03-18

  The invention relates to a cosmetic composition containing at least one 15-hydroxyprostaglandin dehydrogenase inhibitor and cosmetically acceptable excipients. It also relates to a method of cosmetic treatment for promoting the growth and/or preventing or delaying the loss of hair, and the use of a 15-hydroxyprostaglandin dehydrogenase inhibitor for the preparation of a composition intended for controlling hair loss and/or for promoting hair regrowth.

  本发明涉及一种化妆品组合物，其含有至少一种15-羟基前列腺素脱氢酶抑制剂和化妆品可接受的辅料。本发明还涉及一种促进头发生长和/或预防或延迟脱发的化妆品治疗方法，以及使用15-羟基前列腺素脱氢酶抑制剂制备用于控制脱发和/或促进头发再生的组合物的用途。