4-nitrothiazol-2-amine | 68969-22-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-nitrothiazol-2-amine
• 英文别名: 2-amino-4-nitrothiazole；2-amino-5-nitrothiazole；Thiazole, aminonitro-；4-nitro-1,3-thiazol-2-amine
• CAS: 68969-22-2
• 化学式: C₃H₃N₃O₂S
• 分子量: 145.142
• InChiKey: GGWJFTHFCOPBSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,6-dichlorobenzoyl isocyanate 、 4-nitrothiazol-2-amine 生成 2,6-dichloro-N-[(4-nitro-1,3-thiazol-2-yl)carbamoyl]benzamide
  参考文献：
  名称：

  YABUTA, GORO;TAGUCHI, RYUSUKE;NAGATO, SHOIN;TOKUMURA, JUN;YAMADA, OSAMU, TOKE NOGE DAJGAKU. NOGAKU SYUXO, 34,(1990) N, S. 179-185

  摘要：

  DOI：

文献信息

• New Solid Phase Synthesis of Distamycin Analogues
  作者：Drozdowska Danuta

  DOI：10.3390/molecules16043066

  日期：——

  A novel and straightforward solid phase synthesis of distamycin analogues containing benzene units has been developed.

  已开发出一种新颖且简单的固相合成方法，用于合成含有苯单位的二酸霉素类似物。
• Green and one-pot synthesis of novel amidoalkyl naphthols using triethanolammonium acetate [(OHCH2CH2)3NH][OAc]) ionic liquid and their anti-H.pylori activity
  作者：Mohammad Amin Manavi、Mohammad Hosein Fathian Nasab、Fatemeh Dashti、Setareh Moghimi、Parastoo Saniee、Behjat Pouramiri、Alireza Foroumadi、Morteza Pirali-Hamedani

  DOI：10.1007/s11164-022-04803-9

  日期：2022.10

  one-pot synthesis of amidoalkyl naphthol derivatives and their in vitro anti-Helicobacter pylori activity are reported. The reaction proceeds via multi-component condensation of 2-naphthol, (hetero) aromatic aldehydes and urea/thiourea/acetamide/2-aminothiazole/4-nitrothiazol-2-amine/2-aminopyridine under solvent-free condition. This protocol includes some salient features, such as using triethanolammonium

  世界上近一半的人口感染了幽门螺杆菌（H. pylori），幽门螺杆菌被认为是导致慢性胃炎、十二指肠溃疡和胃癌的主要原因。在这项工作中，报道了一种高效的一锅法合成氨基烷基萘酚衍生物及其体外抗幽门螺杆菌活性。该反应通过2-萘酚、（杂）芳香醛和脲/硫脲/乙酰胺/2-氨基噻唑/4-硝基噻唑-2-胺/2-氨基吡啶在无溶剂条件下的多组分缩合进行。该协议包括一些显着特点，例如使用醋酸三乙醇铵 ([OHCH 2 CH 2 ) 3NH][OAc])离子液体作为一种绿色、清洁、可重复使用的催化剂，收率高，无需柱层析，成本低。通过比较目标化合物的抑菌圈，可以认为6e和6j是最好的抗螺杆菌药物。
• New sulfonamide-tethered coumarin derivatives as potential DNA gyrase inhibitors: Design, synthesis, antimicrobial evaluation, and in silico study
  作者：Heba M. Abo-Salem、Eman AboBakr Ali、Shaima A. El-Mowafi、Mohamed S. Abdel-Aziz、Eslam R. El-Sawy、Hayam A. Abd El Salam

  DOI：10.1016/j.molstruc.2023.136860

  日期：2024.1

  A new series of coumarin-6-sulfonamide derivatives 3-16 have been synthesized via simple and convenient coupling reaction of coumarin-6-sulfonyl chloride with different sulfa drugs and various amino-heterocycles. The antimicrobial activity of the new compounds was evaluated against S. aureus ATCC 6538, E. coli ATCC 25933, C. albicans ATCC 10231, and A. niger NRRL A-326. Compound 12 showed potent antimicrobial

  通过香豆素-6-磺酰氯与不同磺胺类药物及多种氨基杂环的简单、便捷的偶联反应，合成了一系列新的香豆素-6-磺酰胺衍生物3-16 。评估了新化合物针对金黄色葡萄球菌ATCC 6538、大肠杆菌ATCC 25933、白色念珠菌ATCC 10231 和黑曲霉NRRL A-326 的抗菌活性。化合物 12 对所有致病菌株均表现出有效的抗菌活性，对金黄色葡萄球菌的 MIC 值为 4.88 μg/mL，对白色念珠菌的 MIC值为9.76 μg/mL ，比新霉素对照药物强 4 倍（MIC= 19.53 和 39.06 μg） /mL），对大肠杆菌的 MIC 值为 39.06 μg/mL ，与新霉素等效。同时，化合物10与新霉素对金黄色葡萄球菌和白色念珠菌具有同等功效。此外，化合物14与新霉素对抗金黄色葡萄球菌的功效相当，并且比新霉素对抗白色念珠菌的功效强2倍。进一步研究表明，化合物10和12强烈抑制DNA旋转酶（IC
• Paramagnetic charge transfer complexes: new molecular composites via intercalation of thiazole and benzothiazole derivatives within the cavities of the 3D host polymers [(Me3E)3Fe(CN)6]∞; E - Sn or Pb
  作者：Amany M.A. Ibrahim、Safaa El Din H. Etaiw

  DOI：10.1016/s0277-5387(96)00484-6

  日期：1997.3

  The three-dimensional (3D) polymers [(Me(3)Sn)(3)Fe(CN)(6)](infinity) (I) and [(Me(3)pb)(3)Fe(CN)(6)](infinity) (II) which have wide internal cavities capable of incapsulating voluminous organic compounds behave as host accepters forming charge transfer complexes (CTC). Thiazole and benzothiazole derivatives acting as guest donor species are encapsulated within the cavities of the 3D polymeric hosts I or II forming yellow to green or red CTC having, in some cases, semiconducting properties. Some of the donors containing an amino group undergo polymerization within the cavities of the host polymers forming new molecular composites having pronounced electrical conductivity when doped in 2 M HCl solution. The interesting feature of these composites is the enhanced electronic conductivities exhibited by encapsulation of the conductive polymers within the cavities of the host 3D polymers. (C) 1997 Elsevier Science Ltd.
• YABUTA, GORO;TAGUCHI, RYUSUKE;NAGATO, SHOIN;TOKUMURA, JUN;YAMADA, OSAMU, TOKE NOGE DAJGAKU. NOGAKU SYUXO, 34,(1990) N, S. 179-185
  作者：YABUTA, GORO、TAGUCHI, RYUSUKE、NAGATO, SHOIN、TOKUMURA, JUN、YAMADA, OSAMU

  DOI：——

  日期：——