5-(1,1-Dimethylpropyl)-5H-tetrazole | 86842-35-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(1,1-Dimethylpropyl)-5H-tetrazole
• 英文别名: 5-(2-methylbutan-2-yl)-2H-tetrazole
• CAS: 86842-35-5
• 化学式: C₆H₁₂N₄
• 分子量: 140.19
• InChiKey: FGCGZUFQSOYAJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  54.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Fused Heterocyclic Compounds as Ion Channel Modulators
  申请人：Kobayashi Tetsuya

  公开号：US20120010192A1

  公开（公告）日：2012-01-12

  The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein R 1 , R 2 , R 3 , R 4 , and R 5 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

  本公开涉及一类是钠通道抑制剂的化合物，以及它们在治疗各种疾病状态中的应用，包括心血管疾病和糖尿病。在特定实施例中，该类化合物的结构由式I给出：其中R1、R2、R3、R4和R5如本文所述，以及制备和使用该类化合物的方法，以及含有这些化合物的药物组合物。
• FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS
  申请人：Corkey Britton

  公开号：US20110021521A1

  公开（公告）日：2011-01-27

  The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein W 1 , W 2 , W 3 , R 1 , Q, X 1 , X 2 and X 3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

  本发明涉及一类钠通道抑制剂化合物，以及它们在治疗各种疾病状态中的应用，包括心血管疾病和糖尿病。具体实施例中，该化合物的结构由下式给出：其中W1、W2、W3、R1、Q、X1、X2和X3如本文所述，以及制备和使用该化合物的方法，以及含有该化合物的药物组合物。
• EP4 antagonists
  申请人：Eisai R&D Management Co., Ltd.

  公开号：US10316040B2

  公开（公告）日：2019-06-11

  We provide compounds given by Formula I, which is shown in FIG. 3, or pharmaceutically acceptable salts thereof, as well as formulations thereof and methods of use of those compounds and formulations for treatment of cancer.

  我们提供了如图 3 所示的式 I 所示的化合物或其药学上可接受的盐，以及其制剂和使用这些化合物和制剂治疗癌症的方法。
• Water-based synthesis of poly(tetrazoles) and articles formed therefrom
  申请人：Miller G. Cory

  公开号：US20070040167A1

  公开（公告）日：2007-02-22

  A polyvinyl(tetrazole) is formed by a water-based method. A gas generating composition 12 containing the polyvinyl(tetrazole) is contained within an exemplary gas generator 10. An article or gas generating system 200 incorporates the polyvinyl(tetrazole) therein. A vehicle occupant protection system 180 incorporates the gas generating system 200. An article or substrate 300 containing a coating 302 formed from the product of the water-based method is also described.
• Water-based synthesis of poly(tetrazoles)
  申请人：Miller Cory G.

  公开号：US20080099111A1

  公开（公告）日：2008-05-01

  A poly(tetrazole) is formed by a water-based method. A gas generating composition 12 containing the poly(tetrazole) is contained within an exemplary gas generator 10. A gas generating system 200 incorporates the poly(tetrazole) therein. A vehicle occupant protection system 180 incorporates the gas generating system 200.