5alpha-麦角甾烷 | 511-20-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 5alpha-麦角甾烷
• 中文别名: 5α-麦角甾烷
• 英文名称: (5α)-ergostane
• 英文别名: 5α-cholestane；ergostane；5α-ergostane；5α-Ergostan；(24S)-24-methyl-5α-cholestane；5alpha-Ergostane；(5R,8R,9S,10S,13R,14S,17R)-17-[(2R,5S)-5,6-dimethylheptan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene
• CAS: 511-20-6
• 化学式: C₂₈H₅₀
• 分子量: 386.705
• InChiKey: WAAWMJYYKITCGF-WTPIMUJOSA-N

物化性质

• 熔点：
  85°
• 比旋光度：
  D20 +17° (c = 2 in chloroform)
• 沸点：
  447.83°C (rough estimate)
• 密度：
  0.8615 (estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  11.3
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  5alpha-麦角甾烷 、 溶剂黄146 、 alkaline earth salt of/the/ methylsulfuric acid 生成 24-nor-5α-cholanoic acid-(23)
  参考文献：
  名称：

  Chuang, Justus Liebigs Annalen der Chemie, 1933, vol. 500, p. 270,273, 277

  摘要：

  DOI：
• 作为产物：
  描述：

  5α-ergostene-(14) 在 溶剂黄146 、 乙酸乙酯 、 铂 作用下， 生成 5alpha-麦角甾烷
  参考文献：
  名称：

  230.固醇类的研究。第十五部分。α-和β-麦芽固醇与它们衍生的烃的关系

  摘要：

  DOI：

  10.1039/jr9320001710

文献信息

• Facile Barton−McCombie Deoxygenation of Alcohols with Tetrabutylammonium Peroxydisulfate and Formate Ion
  作者：Hee Sock Park、Hee Yoon Lee、Yong Hae Kim

  DOI：10.1021/ol050886h

  日期：2005.7.1

  [reaction: see text]. A new method for efficient radical deoxygenation of alcohols is described for preparing bulk chemicals avoiding scale-up problems. Treatment of various thiocarbonyl derivatives with (Bu(4)N)(2)S(2)O(8) and HCO(2)Na in DMF afforded the corresponding deoxygenated products in excellent yields. The deoxygenation appears to be initiated by the transfer of a single electron to thiocarbonyl

  [反应：请参见文字]。描述了一种用于醇的有效自由基脱氧的新方法，用于制备散装化学品以避免规模扩大的问题。用（Bu（4）N）（2）S（2）O（8）和HCO（2）Na在DMF中处理各种硫代羰基衍生物以优异的收率提供了相应的脱氧产物。脱氧似乎是由单个电子从CO（2）（*）（-）而不是SO4（*）（-）转移到硫代羰基衍生物而引发的。
• Marine Sterols. XXI. Isolation of (24S)-6.BETA.-Hydroxyergost-5-en-21-oic Acid from a Sclerophytum sp. of Soft Coral.
  作者：Masaru KOBAYASHI、Bodepudi HARIBABU、Vallurupalli ANJANEYULU

  DOI：10.1248/cpb.40.233

  日期：——

  The lipid extract of the Sclerophytum so. of soft coral, collected off the coast of the Andaman and Nicober Islands, afforded a new sterol 1a. The structure of 1a was shown to be (24S)-3β-hydroxyergost-5-en-21-oic acid, the first member of a class of marine sterols having a C-21 carboxylic acid, by spectral analyses and conversion to(24S)-ergostane.

  在安达曼岛和尼科贝岛海岸采集的软珊瑚中的 Sclerophytum so.的脂质提取物中发现了一种新的固醇 1a。通过光谱分析和转化为(24S)-麦角甾烷，1a 的结构被证明是(24S)-3β-羟基麦角甾-5-烯-21-酸，这是一类具有 C-21 羧酸的海洋甾醇的第一个成员。
• Antiwear Tribofilm Formation on Steel Surfaces Lubricated With Gear Oil Containing Borate, Phosphorus, and Sulfur Additives
  作者：K. Komvopoulos、V. Chiaro、B. Pakter、E. S. Yamaguchi、P. R. Ryason

  DOI：10.1080/10402000208982589

  日期：2002.1

  The formation of antiwear tribofilms plays a critical role in the longevity of automotive gears. The focus of this experimental study was on the lubrication efficacy of gear oils with different contents of borate-, phosphorus-, and sulfur-containing additives leading to the formation of protective tribofilms. Experiments were performed with AISI 52100 steel balls sliding against AISI 52100 steel disks in baths of different oils at ambient (similar to32degreesC) and elevated (similar to100degreesC) temperatures under load and speed conditions favoring sliding in the boundary lubrication regime. Friction coefficient responses accompanied by electrical contact voltage measurements provided real-time information about the formation and durability of the antiwear tribofilms. The wear resistance of the tribochemical films was quantified by wear rate data obtained from surface profilometry measurements of wear tracks on the disk specimens and sliding tests performed at ambient temperatures after the formation of the tribofilms during elevated-temperature sliding. Results indicate a strong dependence of tribofilm formation on temperature and type of additives. The slightly lower friction and higher wear resistance obtained at elevated temperatures with blended oils is attributed to the increased chemical reactivity of additives containing borate, phosphorus, and sulfur, leading to the formation of durable tribofilms. Relatively higher wear resistance and faster tribofilm formation were obtained with the borate-enriched gear oil formulations.
• Robust Parameter Design of Multiple-Target Systems
  作者：V Roshan Joseph、C F Jeff Wu

  DOI：10.1198/004017002188618536

  日期：2002.11

  In multiple-target systems, the signal factor is varied based on the signal-response relationship to achieve different targets for the response specified by the customer. Robust parameter design aims to make the signal-response relationship insensitive to the noise variation by choosing appropriate levels for the control factors. Taguchi's dynamic signal-to-noise ratio has several limitations for the optimization in multiple target systems. We give a theoretical formulation of the problem and develop A practical approach for optimization that overcomes these limitations. The methodology is illustrated using a temperature controller example.
• Fernholz, Chemische Berichte, 1936, vol. 69, p. 1792,1793
  作者：Fernholz

  DOI：——

  日期：——