diethyl bis(3-chloropropyl)malonate | 79899-30-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: diethyl bis(3-chloropropyl)malonate
• 英文别名: Diethyl bis(3-chloropropyl)propanedioate；diethyl 2,2-bis(3-chloropropyl)propanedioate
• CAS: 79899-30-2
• 化学式: C₁₃H₂₂Cl₂O₄
• 分子量: 313.221
• InChiKey: QSQWCEIDFFOOBW-UHFFFAOYSA-N

物化性质

• 熔点：
  52-53 °C(Solv: ethanol (64-17-5))
• 沸点：
  170-175 °C(Press: 8 Torr)
• 密度：
  1.147±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  diethyl bis(3-chloropropyl)malonate 在 碘代三甲硅烷 作用下， 以 四氯化碳 为溶剂， 反应 120.0h， 以83%的产率得到bis(3-chloropropyl)malonic acid
  参考文献：
  名称：

  Biologically oriented organic sulfur chemistry. 22. 2-(3-Chloropropyl)-5-chloropentanol as a prototype for synthesis of functionalized polysulfides and prodrugs

  摘要：

  DOI：

  10.1021/jo00341a008
• 作为产物：
  描述：

  丙二酸二乙酯 、 1-溴-3-氯丙烷 在 四丁基溴化铵 、 环己烯 作用下， 以 乙腈 为溶剂， 以48%的产率得到diethyl bis(3-chloropropyl)malonate
  参考文献：
  名称：

  Cathodic synthesis of cyclobutanes

  摘要：

  Previously we showed that during cathodic electrolysis of compounds with an activated methylene group (CAMG) in the presence of 1,2-dichloroethane [1] or 1,4-dibromobutane [2] a Perkin reaction-type process occurs which affords 1,1-disubstituted cyclopropanes and cyclopentanes, respectively. Continuing the study, we considered the possibility of cathodic synthesis of four-membered alicyclic compounds during electrolysis of compounds with an activated methylene group in the presence of 1,3-dihalopropanes. Usually, cyclobutane derivatives are obtained in the Perkin reaction with somewhat greater difficulty than are their nearest homologs [3]; therefore, alternative methods for the synthesis of cyclobutanes must still be sought.

  DOI：

  10.1007/bf00961301

文献信息

• Aminosilane Compounds, Catalyst Components and Catalysts for Olefin Polymerization, and Process for Production of Olefin Polymers with the Same
  申请人：Hosaka Motoki

  公开号：US20120053310A1

  公开（公告）日：2012-03-01

  A catalyst for polymerization of olefins formed from (A) a solid catalyst component containing magnesium, titanium, halogen, and an electron donor compound, (B) an organoaluminum compound shown by the formula, R 6 p AlQ 3-p , and (C) an aminosilane compound shown by the formula, R 3 n Si(NR 4 R 5 ) 4-n ; and a process for producing a catalyst for polymerization of olefins in the presence of the catalyst are provided. A novel aminosilane compound, a catalyst component for polymerization of olefins having a high catalytic activity, capable of producing polymers with high stereoregularity in a high yield, and exhibiting an excellent hydrogen response, a catalyst, and a process for producing olefin polymers using the catalyst are provided.

  提供了一种用于聚合烯烃的催化剂，其由（A）固体催化剂组分（包含镁、钛、卤素和电子给体化合物）、（B）有机铝化合物（由公式R6pAlQ3-p表示），以及（C）氨基硅烷化合物（由公式R3nSi（NR4R5）4-n表示）形成；并提供了一种在催化剂存在下生产烯烃聚合物的方法。提供了一种新型氨基硅烷化合物、用于聚合烯烃的催化剂组分，具有高催化活性，能够产生高立体异构体收率的聚合物，并表现出优异的氢响应性能，提供了一种催化剂以及使用该催化剂生产烯烃聚合物的方法。
• SOLID CATALYST COMPONENT FOR OLEFIN POLYMERIZATION, CATALYST FOR OLEFIN POLYMERIZATION, AND METHOD FOR PRODUCING OLEFIN POLYMER
  申请人：Uozumi Toshiya

  公开号：US20140221583A1

  公开（公告）日：2014-08-07

  An olefin polymer that is obtained using an olefin polymerization catalyst that includes a solid catalyst component for olefin polymerization that includes titanium, magnesium, a halogen, and an ester compound (A) represented by the following formula (1): R 1 R 2 C═C(COOR 3 )(COOR 4 ), an organoaluminum compound, and an optional external electron donor compound, exhibits primary properties (e.g., molecular weight distribution and stereoregularity) similar to those of an olefin polymer obtained using a solid catalyst component that includes a phthalic ester as an electron donor.

  使用一种包括钛、镁、卤素和酯化合物(A)的固体催化剂组分（式子1：R1R2C═C(COOR3)(COOR4)）进行烯烃聚合得到的烯烃聚合物，加上有机铝化合物和可选的外部电子给体化合物，表现出与包括邻苯二甲酸酯作为电子给体的固体催化剂组分得到的烯烃聚合物相似的主要性质（如分子量分布和立构规则性）。
• CATALYST FOR POLYMERIZATION OF OLEFINS AND METHOD FOR POLYMERIZATION OF OLEFINS
  申请人：Toho Catalyst Co., Ltd.

  公开号：EP1790667A1

  公开（公告）日：2007-05-30

  A catalyst for olefin polymerization comprising (A) a solid catalyst component prepared by causing (a) a magnesium compound, (b) a tetravalent titanium halide compound, and (c) an electron donor compound to come in contact with each other, (B) an organoaluminum compound of the general formula R1pAlQ3-p, and (C) an oligomer of an organosilicon compound of the following chemical formula; R4-(R2R3SiO)m-R5 can produce olefin polymers having higher stereoregularity and a broader molecular weight distribution in a higher yield than conventional catalysts.

  一种用于烯烃聚合的催化剂，包括(A)通过使(a)镁化合物、(b)四价卤化钛化合物和(c)电子供体化合物相互接触而制备的固体催化剂组分，(B)通式为 R1pAlQ3-p 的有机铝化合物，和(C)化学式如下的有机硅化合物的低聚物；与传统催化剂相比，R4-(R2R3SiO)m-R5 能以更高的产率生产出立体规整度更高，分子量分布更广的烯烃聚合物。
• SOLID CATALYST COMPONENT AND CATALYST FOR POLYMERIZATION OF OLEFIN, AND METHOD FOR PRODUCING POLYMER OR COPOLYMER OF OLEFIN USING THE SAME
  申请人：Toho Catalyst Co., Ltd.

  公开号：EP1829898A1

  公开（公告）日：2007-09-05

  A catalyst for polymerization of olefins and a process for producing an olefin polymer or copolymer are disclosed. The catalyst comprises (a) a solid catalyst component obtained by causing an organosilicon compound (b) represented by the formula, [CH2=CH-(CH2)n]qSiR34-q, and an organoaluminum compound to come in contact with a solid component comprising magnesium, titanium, halogen, and an electron donor compound, or a solid catalyst component obtained by causing a magnesium compound, two types of titanium compounds, an electron donor compound, and an organosilicon compound to come in contact with each other, and (B) an organoaluminum compound. The process for producing an olefin polymer or copolymer comprises polymerizing olefins in the presence of the catalyst. The catalyst has a high catalytic activity, exhibits excellent hydrogen response, and can produce polymers with high stereoregularity and a broad molecular weight distribution at a high yield.

  本发明公开了一种烯烃聚合催化剂和一种生产烯烃聚合物或共聚物的工艺。该催化剂包括：(a) 一种固体催化剂组分，通过使一种由式[CH2=CH-(CH2)n]qSiR34-q表示的有机硅化合物(b)和一种有机铝化合物与一种由镁、钛、卤素和一种电子供体化合物组成的固体组分接触而得到；或一种固体催化剂组分，通过使一种镁化合物、两种钛化合物、一种电子供体化合物和一种有机硅化合物相互接触而得到；以及(B) 一种有机铝化合物。生产烯烃聚合物或共聚物的工艺包括在催化剂存在下聚合烯烃。该催化剂具有很高的催化活性，表现出优异的氢响应，并能以高产率生产出立体规整度高、分子量分布广的聚合物。
• CATALYST COMPONENT AND CATALYST FOR OLEFIN POLYMERIZATION AND METHOD FOR PRODUCING OLEFIN POLYMER USING THOSE
  申请人：Toho Catalyst Co., Ltd.

  公开号：EP1921092A1

  公开（公告）日：2008-05-14

  A polymer having high catalyst activity, excellent hydrogen response, high stereoregularity and high yield can be obtained by polymerizing olefins in the presence of a catalyst for olefin polymerization comprising (A) a solid catalyst component containing magnesium, titanium, a halogen,, and an electron donor compound, (B) an organoaluminum compound shown by the formula R6pAlQ3-p (R1R2N)m, and (C) an aminosilane compound shown by the formula (R3HN)nR4pSi(OR5)q.

  通过在烯烃聚合催化剂存在下聚合烯烃，可获得一种具有高催化剂活性、优异氢响应、高立体规整度和高产率的聚合物，烯烃聚合催化剂由以下部分组成：(A)含有镁、钛、卤素和电子供体化合物的固体催化剂组分；(B)式 R6pAlQ3-p (R1R2N)m 所示的有机铝化合物；以及(C)式 (R3HN)nR4pSi(OR5)q 所示的氨基硅烷化合物。