ethyl 2-dodecylpropenoate | 84515-40-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl 2-dodecylpropenoate
• 英文别名: Ethyl 2-methylidenetetradecanoate
• CAS: 84515-40-2
• 化学式: C₁₇H₃₂O₂
• 分子量: 268.44
• InChiKey: KDXGWJYXMJDPAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  19
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  ethyl 2-dodecylpropenoate 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 benzyl (3S)-2-[[(2S)-2-ethoxycarbonyltetradecyl]-ethylcarbamoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylate
  参考文献：
  名称：

  血管紧张素转化酶抑制剂的研究。三，2-羧乙基氨基甲酰基-1,2,3,4-四氢异喹啉-3-羧酸衍生物。

  摘要：

  (3S)-2-[N-取代的N-(2-羧乙基)氨基甲酸]-1, 2, 3, 4-四氢异喹啉-3-羧酸衍生物 (8a-d 和 12a-t) 及其单酯化合物 (13a-k) 通过 (3S)-1, 2, 3, 4-四氢异喹啉-3-羧酸酯 (6a, b)、3-氨基丙酸酯 (5a, b 或 10a-m) 和氯仿的缩合反应合成，随后去保护酯基。评估了它们在体外的血管紧张素转化酶 (ACE) 抑制活性及抗高血压效果，并讨论了结构-活性关系。一些具有疏水取代基（C8H17-C12H25，CH2CH2Ph）在侧链α位与羧基相邻的N-乙基氨基甲酸类似物 (12h, 12j, 12k, 12l 和 12o) 显示出强大的体外ACE抑制活性，IC50值为4.0-8.8×10^-9M。单酯化合物13e、13h和13i在口服剂量为50mg/kg时，能使自发性高血压大鼠 (SHR) 的收缩压下降超过30 mmHg。

  DOI：

  10.1248/cpb.33.2011
• 作为产物：
  描述：

  十二醛二甲缩醛 在 偶氮二异丁腈 、 对甲苯磺酸 作用下， 以 环己烷 为溶剂， 反应 12.0h， 生成 ethyl 2-dodecylpropenoate
  参考文献：
  名称：

  分子内均溶位移。30.通过不饱和过氧缩醛的均相诱导分解，醛的功能性脱羰基转化

  摘要：

  由醛合成的不饱和过氧缩醛的均相诱导分解产生了烷氧基烷氧基，该烷氧基通过快速的β断裂产生了烷基。后者可以与几种类型的“转移剂”发生反应，从而平稳地将醛类的均相脱羰基官能团转化为卤化物，烃，黄原酸酯，链烷腈，2-烷基-3-氯马来酸酐，1-苯基烷-1-炔，和2-烷基丙烯酸乙酯。

  DOI：

  10.1021/jo9918495

文献信息

• Molecular Healing of Polymeric Materials, Coatings, Plastics, Elastomers, Composites, Laminates, Adhesives, and Sealants by Active Enzymes
  申请人：McDaniel C. Steven

  公开号：US20100210745A1

  公开（公告）日：2010-08-19

  Disclosed herein are polymeric materials such as a coating, a plastic, a laminate, a composite, an elastomer, an adhesive, or a sealant; a surface treatment such as a textile finish or a wax; a filler for such a polymeric material or a surface treatment that includes an enzyme such as an esterase (e.g., a lipolytic enzyme, a sulfuric ester hydrolase, an organophosphorus compound degradation enzyme), an enzyme (e.g., a lysozyme, a lytic transglycosylase) that degrades a cell wall and/or a cell membrane component, a biocidal or biostatic peotide, and/or a peptidase. Also disclosed herein are methods of altering a material's property such as service life, flexability, or rigidity, by incorporation of an enzyme into a material capable of being chemically crosslinked by the activity of a lipolytic enzyme, a hydrolase, and/or a urease.

  本文公开了一些聚合材料，如涂层、塑料、层压板、复合材料、弹性体、粘合剂或密封剂；一种表面处理，如纺织品涂层或蜡；一种填料，用于这样的聚合材料或表面处理，其中包括一种酶，如酯酶（例如，脂肪水解酶，硫酸酯水解酶，有机磷化合物降解酶），降解细胞壁和/或细胞膜成分的酶（例如，溶菌酶，裂解转糖基酶），生物杀菌或生物静态肽，以及/或肽酶。本文还公开了通过将酶纳入可通过脂肪水解酶、水解酶和/或脲酶的活性交联材料中来改变材料性能，如使用寿命、柔韧性或刚度的方法。
• Anti-fouling Paints and Coatings
  申请人：Reactive Surfaces LTD

  公开号：US20150191607A1

  公开（公告）日：2015-07-09

  Disclosed herein are polymeric materials such as a coating, a plastic, a laminate, a composite, an elastomer, an adhesive, or a sealant; a surface treatment such as a textile finish or a wax; a filler for such a polymeric material or a surface treatment that includes an enzyme such as an esterase (e.g., a lipolytic enzyme, a sulfuric ester hydrolase, an organophosphorus compound degradation enzyme), an enzyme (e.g., a lysozyme, a lytic transglycosylase) that degrades a cell wall and/or a cell membrane component, a biocidal or biostatic peptide, and/or a peptidase. Also disclosed herein are methods of altering a material's property such as service life, flexability, or rigidity, by incorporation of an enzyme into a material capable of being chemically crosslinked by the activity of a lipolytic enzyme, a hydrolase, and/or a urease.

  本文披露了聚合材料，例如涂层、塑料、层压材料、复合材料、弹性体、粘合剂或密封剂；表面处理，例如纺织品整理或蜡；填充剂，用于这种聚合材料或表面处理，包括酯酶（例如脂肪水解酶、硫酸酯水解酶、有机磷化合物降解酶）的酶，降解细胞壁和/或细胞膜成分的酶（例如溶菌酶、裂解转葡糖苷酶），生物杀菌或生物稳定肽，和/或肽酶。本文还披露了通过将酶并入能够通过脂肪水解酶、水解酶和/或脲酶的活性进行化学交联的材料中，改变材料性能（例如使用寿命、柔韧性或刚度）的方法。
• Process for coating thermoplastic substrates with a coating composition containing a non-aggressive solvent
  申请人：——

  公开号：US20010053417A1

  公开（公告）日：2001-12-20

  A process for coating a thermoplastic substrate which comprises applying a solvent based coating composition to the substrate and curing the coating composition at ambient temperature to 125° C. to form a uniform smooth film on the substrate; wherein the coating composition contains about 45-80% by weight of a film forming binder and 20-55% by weight of an organic liquid carrier; wherein the binder contains (A) 40-90% by weight, based on the weight of the binder, of a polymer selected from the following: acrylic polyol, polyester polyol, polyether polyol or a polyurethane polyol; and (B) 10-60% by weight, based on the weight of the binder, of an organic polyisocyanate crosslinking agent; and wherein the organic liquid carrier used in the coating composition comprises at least 50% by weight, based on the weight of the organic liquid carrier used in the coating composition, of tertiary butyl acetate; the process of this invention also can be used to apply lacquers, i.e., coating composition that do not contain a crosslinking agent such as a polyisocyanate.

  一种涂覆热塑性基材的工艺，包括将溶剂型涂料组合物涂覆到基材上，并在环境温度至 125°C 下固化涂料组合物，以便在基材上形成均匀光滑的薄膜； 其中涂层组合物含有约 45-80%（按重量计）的成膜粘合剂和 20-55%（按重量计）的有机液体载体；其中粘合剂含有 (A) 以粘合剂重量计，40-90%（以重量计）选自下列的聚合物：丙烯酸多元醇、聚酯多元醇、聚醚多元醇或聚氨酯多元醇；和 (B) 10-60%（以粘合剂重量计）的有机多异氰酸酯交联剂；以及 本发明的工艺也可用于涂漆，即不含多异氰酸酯等交联剂的涂料组合物。
• High acid aqueous nanocomposite dispersions
  申请人：——

  公开号：US20020055580A1

  公开（公告）日：2002-05-09

  The present invention is directed to, in part, polymer clay nanocomposites having an acid containing monomer and clay. In one embodiment, there is provided a process for preparing an aqueous polymer clay nanocomposite dispersion, wherein the process comprises: providing an aqueous dispersion comprising at least one clay, optionally at least one ethylenically unsaturated monomer, and optionally at least one surfactant; providing a monomer mixture comprising at least 10% by weight of an acid containing monomer within the monomer mixture and optionally a surfactant; mixing the aqueous dispersion and the monomer mixture; and polymerizing the monomer to form the nanocomposite dispersion wherein the clay is at least partially exfoliated within the nanocomposite dispersion. The present invention also relates to the use of these compositions such as thickeners, dispersants, plastics additives, adhesives, coatings, flexographic inks, overprint varnishes, and dry cement powder modifiers.

  本发明部分涉及具有含酸单体和粘土的聚合物粘土纳米复合材料。在一个实施方案中，提供了一种制备含水聚合物粘土纳米复合材料分散体的工艺，其中该工艺包括提供包含至少一种粘土、任选的至少一种乙烯基不饱和单体和任选的至少一种表面活性剂的水性分散体； 提供单体混合物，该单体混合物包含至少 10%（按重量计）的含酸单体和任选的表面活性剂； 混合水性分散体和单体混合物；以及 聚合单体以形成纳米复合分散体，其中粘土在纳米复合分散体中至少部分剥离。本发明还涉及这些组合物的用途，如增稠剂、分散剂、塑料添加剂、粘合剂、涂料、柔性版印刷油墨、罩光油和干水泥粉改性剂。
• Copolymers comprising low surface tension (meth) acrylates
  申请人：——

  公开号：US20030096929A1

  公开（公告）日：2003-05-22

  The present invention is directed to a copolymer that includes a first radically polymerizable low surface tension (meth)acrylate monomer and one or more other radically polymerizable ethylenically unsaturated monomers. The copolymer has a polydispersity index of less than 2.5. The present invention further includes a controlled radical polymerization method to make the above described low surface tension containing copolymers. The method includes the steps of adding a first radically polymerizable low surface tension (meth)acrylate monomer and one or more other radically polymerizable ethylenically unsaturated monomers to a solution containing a suitable atom transfer radical polymerization (ATRP) initiator.

  本发明涉及一种共聚物，它包括第一种可辐射聚合的低表面张力（甲基）丙烯酸酯单体和一种或多种其他可辐射聚合的乙烯基不饱和单体。共聚物的多分散指数小于 2.5。本发明还包括一种制造上述低表面张力共聚物的受控自由基聚合方法。该方法包括以下步骤：将第一种可自由基聚合的低表面张力（甲基）丙烯酸酯单体和一种或多种其它可自由基聚合的乙烯基不饱和单体加入到含有合适的原子转移自由基聚合（ATRP）引发剂的溶液中。