(E)-1-(1-methyl-2-oxoindolin-3-ylidene)ethyl acetate | 1023304-85-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (E)-1-(1-methyl-2-oxoindolin-3-ylidene)ethyl acetate
• 英文别名: [(1E)-1-(1-methyl-2-oxoindol-3-ylidene)ethyl] acetate
• CAS: 1023304-85-9
• 化学式: C₁₃H₁₃NO₃
• 分子量: 231.251
• InChiKey: QLCOOUOCFWZXOU-XYOKQWHBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-methyl-N-phenylbut-2-ynamide 、 溶剂黄146 在 碘苯二乙酸 、 palladium diacetate 作用下， 以93%的产率得到(E)-1-(1-methyl-2-oxoindolin-3-ylidene)ethyl acetate
  参考文献：
  名称：

  Synthesis of (2-Oxoindolin-3-ylidene)methyl Acetates Involving a C−H Functionalization Process

  摘要：

  [GRAPHICS]A novel palladium-catalyzed oxidative C-H functionalization protocol for the synthesis of (2-oxoindolin-3-ylidene)methyl acetates has been developed. In the presence of Pd(OAC)(2) and Phl(OAC)(2), a variety of N-arylpropiolamides underwent the C-H functionalization reaction with acids to afford the corresponding (E)-(2-oxoindolin-3-ylidene)methyl acetates selectively in moderate to excellent yields.

  DOI：

  10.1021/ol8006315

文献信息

• Synthesis of (2-Oxoindolin-3-ylidene)methyl Acetates Involving a C−H Functionalization Process
  作者：Shi Tang、Peng Peng、Zhi-Qiang Wang、Bo-Xiao Tang、Chen-Liang Deng、Jin-Heng Li、Ping Zhong、Nai-Xing Wang

  DOI：10.1021/ol8006315

  日期：2008.5.1

  [GRAPHICS]A novel palladium-catalyzed oxidative C-H functionalization protocol for the synthesis of (2-oxoindolin-3-ylidene)methyl acetates has been developed. In the presence of Pd(OAC)(2) and Phl(OAC)(2), a variety of N-arylpropiolamides underwent the C-H functionalization reaction with acids to afford the corresponding (E)-(2-oxoindolin-3-ylidene)methyl acetates selectively in moderate to excellent yields.