4-[2-Bromo-3-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)prop-2-enoyl]benzoic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 4-[2-Bromo-3-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)prop-2-enoyl]benzoic acid
• 英文别名: 4-[2-bromo-3-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)prop-2-enoyl]benzoic acid
• 化学式: C₂₅H₂₇BrO₃
• 分子量: 455.4
• InChiKey: MGDDWVJRJABNOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Conversion of apoptotic proteins
  申请人：——

  公开号：US20040220097A1

  公开（公告）日：2004-11-04

  Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-X L are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.
• Compounds that regulate apoptosis
  申请人：Satterthwait Arnold

  公开号：US20070054863A1

  公开（公告）日：2007-03-08

  Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and related Bcl-2 family members are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing or preventing apoptosis are described, together with methods for identifying molecules that induce or prevent apoptosis through interaction with Bcl-2-family members. Methods for treatment of proliferative diseases and neurodegenerative diseases using the modulators of Bcl-2 and related family members are also disclosed.
• CONVERSION OF APOPTOTIC PROTEINS
  申请人：Reed C. John

  公开号：US20070117753A1

  公开（公告）日：2007-05-24

  Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-X L are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.
• METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS
  申请人：Reed John C.

  公开号：US20090118135A1

  公开（公告）日：2009-05-07

  An assay for determining compounds that inhibit activity of a BCl-2 protein, or affect conversion of Bcl-2 from an antiapoptotic to a proapoptotic form are described. In addition, compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and related Bcl-2 family members are identified.
• METHODS OF REGULATING APOPTOSIS
  申请人：Satterthwait Arnold

  公开号：US20100292145A1

  公开（公告）日：2010-11-18

  Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and related Bcl-2 family members are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing or preventing apoptosis are described, together with methods for identifying molecules that induce or prevent apoptosis through interaction with Bcl-2-family members. Methods for treatment of proliferative diseases and neurodegenerative diseases using the modulators of Bcl-2 and related family members are also disclosed.