Ethyl 5-amino-2-methylsulfanyl-3-(4-propan-2-ylphenyl)imidazole-4-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: Ethyl 5-amino-2-methylsulfanyl-3-(4-propan-2-ylphenyl)imidazole-4-carboxylate
• 化学式: C₁₆H₂₁N₃O₂S
• 分子量: 319.4
• InChiKey: RQTQERGUSOBGRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  95.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Imidazole Variants as Modulators of Gaba Receptor For the Treatment of Gi Disorders
  申请人：Bauer Udo

  公开号：US20080269216A1

  公开（公告）日：2008-10-30

  The present invention relates to novel compounds having a positive allosteric GÀBAB receptor (GDR) modulator effect, methods for the preparation of said compounds and to their use, optionally in combination with a GABAB agonist, for the inhibition of transient lower esophageal sphincter relaxations, for the treatment of gastroesophageal reflux disease, as well as for the treatment of functional gastrointestinal disorders and irritable bowel syndrome (IBS). A compound of the general formula I
• US7718686B2
  申请人：——

  公开号：US7718686B2

  公开（公告）日：2010-05-18